Giovannini M, Longhi R, Besana R, Michos N, Sarchi C
Arzneimittelforschung. 1986 Jun;36(6):959-64.
In a single-blind study, 60 children in two age groups (30 patients: 6 months to 3 years; 30 patients: 3 years to 12 years), were orally treated with either alpha-methyl-4-(2-thienyl-carbonyl)phenylacetic acid (suprofen, Suprol), syrup 10 mg/ml or metamizole drops 50% for a maximum period of 4 days, up to 4 times a day. The children presented with high fever due to bacterial or virus infections. Body temperature, pulse rate, and respiratory rate were evaluated at the beginning and then 30 min, 1, 1 1/2, 2, 3, 4, 5, and 6 h after the first administration of the respective drug. Significant differences between the drugs were found for all variables; this demonstrated that with suprofen the antipyretic effect set in more rapidly than with the reference drug. No side-effects were observed in children treated with suprofen syrup. Two patients showed adverse effects, i.e. sweating and hypotension, during the treatment with metamizole. Due to its good antipyretic effect and good tolerability, suprofen appears to be particularly useful for symptomatic treatment of pediatric patients with fever caused by bacterial or virus infections.
在一项单盲研究中，60名两个年龄组的儿童（30名患者：6个月至3岁；30名患者：3岁至12岁），口服α-甲基-4-（2-噻吩基羰基）苯乙酸（舒洛芬，Suprol）糖浆10mg/ml或安乃近滴剂50%，最长治疗4天，每日最多4次。这些儿童因细菌或病毒感染出现高热。在首次服用相应药物前以及服药后30分钟、1小时、1个半小时、2小时、3小时、4小时、5小时和6小时评估体温、脉搏率和呼吸率。所有变量在两种药物之间均发现显著差异；这表明舒洛芬的退热作用比参比药物起效更快。服用舒洛芬糖浆的儿童未观察到副作用。两名患者在使用安乃近治疗期间出现不良反应，即出汗和低血压。由于舒洛芬具有良好的退热作用和耐受性，它似乎特别适用于对因细菌或病毒感染引起发热的儿科患者进行对症治疗。
