von Szeged A V, Michos N
Arzneimittelforschung. 1986 Jul;36(7):1110-2.
The analgesic effect and the tolerability of alpha-methyl-4-(2-thienyl-carbonyl)phenylacetic acid (suprofen, Suprol) syrup 200 mg and metamizole syrup 500 mg were compared in a randomized single-blind study including hospitalized patients with severe to moderate chronic pain. The 2 treatment groups consisted of 30 subjects each and were homogeneous as to the demographic data. Pain intensity was appreciated by the investigator prior to the treatment and on days 2, 3, and 5 of the study; pain relief was assessed on days 2, 3, and 5 of the therapy. Although pain intensity was on treatment with suprofen more markedly reduced than with metamizole, there was no statistically significant difference between the 2 treatment groups (chi 2-test). The Mann-Whitney test revealed that on days 3 and 5 pain relief with suprofen was significantly superior to that with metamizole. According to the investigator's final global evaluation, suprofen syrup 200 mg had very good to good effect in 70% of the cases, whereas the effectiveness of metamizole was rated good to very good in 44%. Side-effects manifesting themselves as gastric irritation and nausea were recorded for 3 patients on suprofen and 2 subjects on metamizole.
在一项随机单盲研究中，对200毫克α-甲基-4-（2-噻吩基羰基）苯乙酸（舒洛芬，Suprol）糖浆和500毫克安乃近糖浆的镇痛效果及耐受性进行了比较，该研究纳入了患有中重度慢性疼痛的住院患者。两个治疗组各由30名受试者组成，在人口统计学数据方面具有同质性。在治疗前以及研究的第2、3和5天，由研究者评估疼痛强度；在治疗的第2、3和5天评估疼痛缓解情况。尽管舒洛芬治疗时疼痛强度的降低比安乃近更明显，但两个治疗组之间无统计学显著差异（卡方检验）。曼-惠特尼检验显示，在第3天和第5天，舒洛芬的止痛效果显著优于安乃近。根据研究者的最终总体评估，200毫克舒洛芬糖浆在70%的病例中具有非常好到良好的效果，而安乃近的有效性在44%的病例中被评为良好到非常好。服用舒洛芬的3名患者和服用安乃近的2名受试者出现了表现为胃部刺激和恶心的副作用。
