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长新冠发病机制的早期线索。

Early clues regarding the pathogenesis of long-COVID.

机构信息

Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, CA, USA.

Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, CA, USA.

出版信息

Trends Immunol. 2022 Apr;43(4):268-270. doi: 10.1016/j.it.2022.02.008. Epub 2022 Mar 8.

DOI:10.1016/j.it.2022.02.008
PMID:35272932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8901423/
Abstract

Intense investigation into the predictors and determinants of post-acute sequelae of SARS-CoV-2 infection (PASC), including 'long COVID', is underway. Recent studies provide clues to the mechanisms that might drive this condition, with the goal of identifying host or virus factors that can be intervened upon to prevent or reverse PASC.

摘要

目前正在深入研究 SARS-CoV-2 感染后后遗症（PASC）的预测因素和决定因素，包括“长新冠”。最近的研究为可能导致这种情况的机制提供了线索，目的是确定可以干预的宿主或病毒因素，以预防或逆转 PASC。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab61/8901423/7081bb86a85a/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab61/8901423/7081bb86a85a/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab61/8901423/7081bb86a85a/gr1_lrg.jpg

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本文引用的文献

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Cell. 2022 Mar 3;185(5):881-895.e20. doi: 10.1016/j.cell.2022.01.014. Epub 2022 Jan 25.
2
Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome.急性新冠病毒感染后综合征患者前瞻性队列的肠道微生物组动态变化。
Gut. 2022 Mar;71(3):544-552. doi: 10.1136/gutjnl-2021-325989. Epub 2022 Jan 26.
3
Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome.免疫球蛋白特征可预测 COVID-19 后急性综合征的风险。
medRxiv. 2025 Apr 29:2025.04.28.25326537. doi: 10.1101/2025.04.28.25326537.
4
Identification of soluble biomarkers that associate with distinct manifestations of long COVID.鉴定与长期新冠不同表现相关的可溶性生物标志物。
Nat Immunol. 2025 May;26(5):692-705. doi: 10.1038/s41590-025-02135-5. Epub 2025 Apr 30.
5
Multidisciplinary collaborative guidance on the assessment and treatment of patients with Long COVID: A compendium statement.关于长新冠患者评估与治疗的多学科协作指南：一份概要声明
PM R. 2025 Apr 22. doi: 10.1002/pmrj.13397.
6
Translating animal models of SARS-CoV-2 infection to vascular, neurological and gastrointestinal manifestations of COVID-19.将新冠病毒（SARS-CoV-2）感染的动物模型转化为新冠肺炎的血管、神经和胃肠道表现。
Dis Model Mech. 2025 Sep 1;18(9). doi: 10.1242/dmm.052086. Epub 2025 Apr 8.
7
Understanding and Addressing Long COVID, the Lingering Shadow of COVID-19.了解并应对新冠后遗症，新冠疫情的长期影响
Infect Chemother. 2025 Mar;57(1):179-180. doi: 10.3947/ic.2025.0025.
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