Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Eye (Lond). 2023 Mar;37(4):631-637. doi: 10.1038/s41433-022-02009-2. Epub 2022 Mar 10.
BACKGROUND/OBJECTIVES: As an essential development in the new century, surface ablation procedures have attracted increasing attention. There exists a concern regarding the risk of infectious keratitis. Hence, we aimed to investigate the rate and predisposing factors of infectious keratitis after photorefractive keratectomy (PRK).
SUBJECTS/METHODS: This retrospective study was designed in two phases. First, the rate of post-PRK keratitis of Farabi Eye Hospital was investigated. In other words, the targeted population was the patients who developed keratitis after performing procedure at Farabi Eye Hospital. In the second phase, all the patients with the diagnosis of post-PRK keratitis were studied regardless of the centre where surgery was performed. Patients with the diagnosis of infectious keratitis between 2014 and 2020 were enrolled and following information was analyzed: demographics, presentation time after surgery, perioperative medications, culture results, risk factors, medical treatment, complications, and final visual acuity.
The total number of PRK procedures in our centre was 24,986 (13,253 patients), in which 6 eyes of 5 patients developed keratitis. Beside these 5 patients, 24 referred patients (24 eyes) from the other centres were enrolled. Finally, a total number of 29 patients (30 eyes) were included. Our analysis revealed that manipulation of contact lens, dry eye, and blepharitis were the essential predisposing factors for keratitis development.
The overall post-PRK keratitis occurrence rate of our study was 0.02%. Our observation highlighted the importance of preoperative examination and treatment of the lids and dry eye disease.
背景/目的：作为新世纪的重要发展，表面消融术引起了越来越多的关注。人们担心会发生感染性角膜炎。因此，我们旨在研究准分子激光屈光性角膜切削术（PRK）后感染性角膜炎的发生率和易患因素。
研究对象/方法：本回顾性研究分为两个阶段进行。首先，研究法伯眼科医院 PRK 后角膜炎的发生率。换句话说，目标人群是在法伯眼科医院接受手术后发生角膜炎的患者。在第二阶段，研究了所有诊断为 PRK 后角膜炎的患者，无论手术中心在哪里。纳入了 2014 年至 2020 年诊断为感染性角膜炎的患者，并分析了以下信息：人口统计学资料、术后出现时间、围手术期用药、培养结果、危险因素、药物治疗、并发症和最终视力。
我们中心 PRK 手术总数为 24986 例（13253 例患者），其中 5 例患者的 6 只眼发生了角膜炎。除了这 5 例患者外，还纳入了来自其他中心的 24 例转诊患者（24 只眼）。最终共纳入 29 例患者（30 只眼）。我们的分析表明，接触镜操作、干眼症和睑缘炎是角膜炎发生的重要易感因素。
我们研究的 PRK 后角膜炎总发生率为 0.02%。我们的观察强调了术前检查和治疗眼睑及干眼症的重要性。
