Davies P, Allison A C
Front Biol. 1978;46:143-60.
The complex effects of cytochalasin B on endocytosis and exocytosis are reviewed. Cytochalasin B inhibits phagocytosis by both mononulcear phagocytes and polymorphonuclear leukocytes but it does not affect the micropinocytic activity of mononulear phagocytes and other cell types. Cytochalasin B causes increased selective release of acid hydrolase from phagocytic cells but its effect on other secretory cells is more variable, stimulating secretion by some cell types, inhibiting secretion in others and having no effect at all in some instances. The possible mechanisms of action of cytochalsin B are discussed with particular emphasis being placed on its effect on the activity of various protein components of cellular contractile systems. We suggest that many of the biolgoical effects of cytochalasin B may be accounted for by such effects.
本文综述了细胞松弛素B对胞吞作用和胞吐作用的复杂影响。细胞松弛素B抑制单核吞噬细胞和多形核白细胞的吞噬作用，但不影响单核吞噬细胞和其他细胞类型的微胞饮活性。细胞松弛素B可导致吞噬细胞中酸性水解酶的选择性释放增加，但其对其他分泌细胞的影响则更具多样性，可刺激某些细胞类型的分泌，抑制另一些细胞的分泌，在某些情况下则完全没有作用。文中讨论了细胞松弛素B可能的作用机制，特别强调了其对细胞收缩系统各种蛋白质成分活性的影响。我们认为，细胞松弛素B的许多生物学效应可能是由这些影响所致。
