Naylor J M, Kronfeld D S
Can J Vet Res. 1986 Jul;50(3):402-9.
Groups of four pregnant ewes were allocated to the following feeding and intravenous endotoxin treatments: fed, Escherichia coli endotoxin (50 micrograms/kg X 75), fed, saline, fasted, E. coli endotoxin (50 micrograms/kg X 75) and fasted, saline. Endotoxin administration resulted in depression, fever, hypoglycemia, hypocalcemia and a reduction in nonesterified fatty acid and ketone body concentrations. Depression correlated best with body temperature (r = 0.76), fasted sheep showed smaller increases in body temperature and were less depressed following endotoxin. Three of eight endotoxin treated sheep died, mortality was not related to rectal temperature but was associated with lactic acidosis. Hypoglycemia was not associated with either death or depression. Fed sheep that were unable to stand had lower serum calcium concentrations than standing sheep.
将四只怀孕母羊分为以下几组，进行如下喂养和静脉内毒素处理：喂食、大肠杆菌内毒素（50微克/千克×75），喂食、生理盐水，禁食、大肠杆菌内毒素（50微克/千克×75），禁食、生理盐水。内毒素给药导致抑郁、发热、低血糖、低钙血症以及非酯化脂肪酸和酮体浓度降低。抑郁与体温的相关性最佳（r = 0.76），禁食的绵羊体温升高幅度较小，内毒素处理后抑郁程度较轻。八只接受内毒素处理的绵羊中有三只死亡，死亡率与直肠温度无关，但与乳酸酸中毒有关。低血糖与死亡或抑郁均无关。无法站立的喂食绵羊血清钙浓度低于能够站立的绵羊。
