Romanosky A J, McGuinness O P, Spitzer J J
Circ Shock. 1983;11(4):311-8.
The metabolic clearance rates of ketone bodies were determined in anesthetized dogs following the intravenous administration of either Escherichia coli endotoxin or saline, in order to examine the influence of endotoxin on the efficiency of peripheral ketone body removal. A nonisotopic method was employed for these studies consisting of a stepwise infusion of beta-hydroxybutyrate at three different rates. At each infusion rate, a steady-state arterial concentration was reached, at which time the rate of appearance of ketone bodies equaled their removal rates. Rates of infusion were plotted against the steady-state arterial concentrations, and the reciprocal of the slope of this linear relationship represented the metabolic clearance rate. Administration of endotoxin did not alter the metabolic clearance rate of ketone bodies. The uptake of ketone bodies by the thigh muscles was also unaffected by endotoxin administration. It is concluded, that E. coli endotoxin does not influence the efficiency of peripheral ketone body removal.
为了研究内毒素对外周酮体清除效率的影响，在麻醉犬静脉注射大肠杆菌内毒素或生理盐水后，测定了酮体的代谢清除率。这些研究采用了一种非同位素方法，包括以三种不同速率逐步输注β-羟基丁酸。在每个输注速率下，均达到了稳态动脉浓度，此时酮体的生成速率等于其清除速率。将输注速率与稳态动脉浓度作图，该线性关系斜率的倒数代表代谢清除率。内毒素的给药并未改变酮体的代谢清除率。大腿肌肉对酮体的摄取也不受内毒素给药的影响。得出的结论是，大肠杆菌内毒素不影响外周酮体的清除效率。
