Filkins J P
Circ Shock. 1982;9(3):269-80.
The role of the RES in the alteration of glucose homeostasis was evaluated in male rats treated with S enteritidis endotoxin. Depression of hepatic gluconeogenesis coupled to enhanced peripheral glucose use was substantiated in vivo using the primed-constant infusion technique with 2-3H-D glucose. Immuno-reactive insulin was elevated in the early hyperglycemic phase but declined in endotoxic hypoglycemia. NSILA was elevated in late endotoxin shock. Two monokines--macrophage insulin-like activity (MILA) and macrophage insulin releasing activity (MIRA)--are related to the pathogenesis of endotoxic hypoglycemia.
在用肠炎沙门氏菌内毒素处理的雄性大鼠中评估了网状内皮系统（RES）在葡萄糖稳态改变中的作用。使用2-³H-D葡萄糖的预充-恒速输注技术在体内证实了肝糖异生的抑制与外周葡萄糖利用增强相关。免疫反应性胰岛素在早期高血糖阶段升高，但在内毒素性低血糖时下降。非抑制胰岛素活性因子（NSILA）在内毒素休克后期升高。两种单核因子——巨噬细胞胰岛素样活性（MILA）和巨噬细胞胰岛素释放活性（MIRA）——与内毒素性低血糖的发病机制有关。
