人类胶质母细胞瘤中多能性相关基因的表达
Expression of pluripotency-related genes in human glioblastoma.
作者信息
Rios Álvaro Fabrício Lopes, Tirapelli Daniela Pretti da Cunha, Cirino Mucio Luiz de Assis, Rodrigues Andressa Romualdo, Ramos Ester S, Carlotti Carlos Gilberto
机构信息
Laboratory of Biotechnology, Center for Biosciences and Biotechnology, North Fluminense State University, Campos dos Goytacazes, Rio de Janeiro, Brazil.
Department of Surgery and Anatomy, Ribeirão Preto Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
出版信息
Neurooncol Adv. 2021 Dec 20;4(1):vdab163. doi: 10.1093/noajnl/vdab163. eCollection 2022 Jan-Dec.
BACKGROUND
Cancer is a group of heterogeneous diseases characterized by several disruptions of the genetic and epigenetic components of cell biology. Some types of cancer have been shown to be constituted by a mosaic of cells with variable differentiation states, with more aggressive tumors being more undifferentiated. In most cases, undifferentiated tumor cells express associated embryonic markers such as the OCT4, NANOG, SOX2, and CARM1 genes. The ectopic or reminiscent expression of some master regulator genes of pluripotency has been indicated as the cause of the poorly differentiated state of tumors, and based on the evidence of some reports, can be used as a possible therapeutic target. Considering this information, a more detailed investigation of the expression of pluripotency-associated genes is necessary to evaluate the roles of these genes in the etiology of some tumors and their use targets of therapy.
METHODS
The expression of four pluripotency-related genes was investigated (OCT4, NANOG, SOX2, and CARM1) in the most malignant primary human brain tumor, glioblastoma (GBM).
RESULTS AND CONCLUSION
The results demonstrated a signature of OCT4/SOX2/CARM1 genes and a significant increase of CARM1 expression in GBM cases.
背景
癌症是一组异质性疾病，其特征是细胞生物学的遗传和表观遗传成分出现多种紊乱。已表明某些类型的癌症由具有不同分化状态的细胞镶嵌体构成，侵袭性更强的肿瘤分化程度更低。在大多数情况下，未分化的肿瘤细胞表达相关的胚胎标志物，如OCT4、NANOG、SOX2和CARM1基因。多能性一些主调控基因的异位或残留表达被认为是肿瘤低分化状态的原因，并且根据一些报道的证据，可作为一种可能的治疗靶点。考虑到这些信息，有必要对多能性相关基因的表达进行更详细的研究，以评估这些基因在某些肿瘤病因中的作用及其作为治疗靶点的用途。
方法
研究了四种多能性相关基因（OCT4、NANOG、SOX2和CARM1）在最恶性的原发性人脑肿瘤胶质母细胞瘤（GBM）中的表达。
结果与结论
结果显示了OCT4/SOX2/CARM1基因的特征，并且在GBM病例中CARM1表达显著增加。
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