Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction - Surgery and Cancer, Imperial College London, W12 0NN, UK; West London Gynaecological Cancer Centre, Imperial College Healthcare NHS Trust, London W12 0HS, UK.
Department of Pediatrics, University of California, Los Angeles, USA.
Semin Cancer Biol. 2022 Nov;86(Pt 3):189-198. doi: 10.1016/j.semcancer.2022.03.005. Epub 2022 Mar 8.
The female reproductive tract, similar to other mucosal sites, harbors a specific microbiome commonly dominated by Lactobacillus species (spp.), which has an essential role in maintaining health and homeostasis. Increasing evidence shows that genital tract dysbiosis and/or specific bacteria and cytokines might have an active role in the development and/or progression of HPV infection and cervical intra-epithelial neoplasia (CIN) and as a result cervical cancer. Cross-sectional and longitudinal studies reported that Lactobacillus spp. depletion increases with severity of CIN and that this may negatively affect disease regression rates. It is plausible that Lactobacillus deplete microbiome composition may lead to a pro-inflammatory environment that can increase malignant cell proliferation and HPV E6 and E7 oncogene expression. Future longitudinal cohorts and mechanistic experiments on HPV transfected cells models will further permit exploration of the impact of Lactobacillus spp. on HPV infection.
女性生殖道与其他黏膜部位相似，存在特定的微生物群落，通常以乳杆菌属（spp.）为主导，对维持健康和内稳态具有重要作用。越来越多的证据表明，生殖道菌群失调和/或特定的细菌和细胞因子可能在 HPV 感染和宫颈上皮内瘤变（CIN）的发展和/或进展中发挥积极作用，并导致宫颈癌。横断面和纵向研究报告称，随着 CIN 严重程度的增加，乳杆菌属的消耗会增加，这可能会降低疾病的消退率。合理的假设是，乳杆菌消耗的微生物组组成可能导致促炎环境，从而增加恶性细胞增殖和 HPV E6 和 E7 致癌基因的表达。未来对 HPV 转染细胞模型的纵向队列和机制实验将进一步探索乳杆菌属对 HPV 感染的影响。
