Wu Zeyu, Zhang Shuijun, Guo Wenzhi, He Yuting
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou 450052, China; Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou 450052, China.
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou 450052, China; Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou 450052, China.
Biomed Pharmacother. 2022 May;149:112788. doi: 10.1016/j.biopha.2022.112788. Epub 2022 Mar 9.
Long noncoding RNAs (lncRNAs) are a series of RNA molecules without ability to code proteins. LncRNAs have emerged as significant players in almost all aspects of gene function and regulation and play crucial roles in many human diseases. Particular lncRNAs are deemed to be promising molecular biomarkers used for diagnosing diseases and determining patient prognoses and treatment efficacies. LINC00339 is a new budding lncRNA and much of evidence shows that it is abnormally expressed in multifarious diseases, including endometriosis, cardiomyocyte apoptosis, osteoporosis, digestive-system tumors, respiratory-system tumors, nervous-system tumors, and diseases involving other systems. Additionally, LINC00339 is remarkably associated with different clinical features, such as tumor size, TNM stage, and pathological grade. LINC00339 expression has been proved to upregulate in the aforementioned diseases and has been identified to promote disease occurrence and development. It is also reported that LINC00339 is associated with various cellular events, such as tumor cell proliferation, motility and invasiveness, the expression has also been proved that it is closely related to clinical symptoms in cancer patients. This review summarizes the relationships among expression levels, biological features, clinical symptoms, and regulatory mechanisms of LINC00339 in several diseases and discusses the clinical applications of LINC00339 as a cancer diagnostic, prognostic and treatment efficacy biomarker.
长链非编码RNA（lncRNAs）是一系列没有蛋白质编码能力的RNA分子。lncRNAs已成为基因功能和调控几乎所有方面的重要参与者，并在许多人类疾病中发挥关键作用。特定的lncRNAs被认为是用于疾病诊断、确定患者预后和治疗效果的有前景的分子生物标志物。LINC00339是一种新出现的lncRNA，大量证据表明它在多种疾病中异常表达，包括子宫内膜异位症、心肌细胞凋亡、骨质疏松症、消化系统肿瘤、呼吸系统肿瘤、神经系统肿瘤以及涉及其他系统的疾病。此外，LINC00339与不同的临床特征显著相关，如肿瘤大小、TNM分期和病理分级。已证明LINC00339在上述疾病中表达上调，并已确定其促进疾病的发生和发展。也有报道称LINC00339与各种细胞事件相关，如肿瘤细胞增殖、运动性和侵袭性，其表达也已证明与癌症患者的临床症状密切相关。本综述总结了LINC00339在几种疾病中的表达水平、生物学特征、临床症状和调控机制之间的关系，并讨论了LINC00339作为癌症诊断、预后和治疗效果生物标志物的临床应用。
