D'Egidio Francesco, Lombardozzi Giorgia, Kacem Ben Haj M'Barek Housem E, Mastroiacovo Giada, Alfonsetti Margherita, Cimini Annamaria
Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA.
Life (Basel). 2022 Jul 27;12(8):1125. doi: 10.3390/life12081125.
Neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system and affects 7-10% of the worldwide population. Neuropathic pain can be induced by the use of drugs, including taxanes, thus triggering chemotherapy-induced neuropathic pain or as consequence of metabolic disorders such as diabetes. Neuropathic pain is most often a chronic condition, and can be associated with anxiety and depression; thus, it negatively impacts quality of life. Several pharmacologic approaches exist; however, they can lead numerous adverse effects. From this perspective, the use of nutraceuticals and diet supplements can be helpful in relieve neuropathic pain and related symptoms. In this review, we discuss how diet can radically affect peripheral neuropathy, and we focus on the potential approaches to ameliorate this condition, such as the use of numerous nutritional supplements or probiotics.
神经性疼痛被定义为由躯体感觉神经系统的损伤或疾病引起的疼痛，全球约7% - 10%的人口受其影响。使用包括紫杉烷类在内的药物可诱发神经性疼痛，从而引发化疗诱导的神经性疼痛，或者作为糖尿病等代谢紊乱的结果。神经性疼痛通常是一种慢性疾病，可能与焦虑和抑郁有关；因此，它会对生活质量产生负面影响。目前有几种药物治疗方法；然而，它们可能会导致许多不良反应。从这个角度来看，使用营养保健品和膳食补充剂有助于缓解神经性疼痛及相关症状。在这篇综述中，我们讨论饮食如何从根本上影响周围神经病变，并重点关注改善这种状况的潜在方法，例如使用多种营养补充剂或益生菌。
