Department of Paediatric Dentistry, Medical University of Warsaw, Warsaw, Poland.
Department of Paediatric Dentistry, Medical University of Warsaw, Warsaw, Poland.
Int Dent J. 2022 Aug;72(4):572-577. doi: 10.1016/j.identj.2021.11.014. Epub 2022 Mar 8.
Treatment with glucocorticoids in children with nephrotic syndrome can be the cause of developmental disorders of the masticatory organ and bone or teeth abnormalities. The aim was to assess the frequency and type of dental abnormalities and the correlation of their occurrence with a dosage of glucocorticoids and treatment time in children with idiopathic nephrotic syndrome.
The study group consisted of 31 patients aged 5 to 17 diagnosed with idiopathic steroid-sensitive nephrotic syndrome and 33 overall healthy children. The studies included clinical evaluation of dentition, radiologic diagnostics, and statistical analysis.
In the study group, 77.4% of patients were diagnosed with abnormalities in dental development. Tooth number disorders, presence of persistent deciduous teeth and impacted teeth, abnormal crown or root shape, developmental defects of enamel, pulp stones, and bone structure disorders were identified. Statistical analysis showed significant differences in the average treatment time of glucocorticoids in patients without and with tooth developmental abnormalities.
Long-term use of glucocorticoids in children with nephrotic syndrome promotes the occurrence of developmental abnormalities of the teeth, calcification of the pulp, and disorders of bone tissue metabolism. For this reason, patients with steroid-sensitive nephrotic syndrome should be under the constant care of a dentist.
在患有肾病综合征的儿童中使用糖皮质激素治疗可能导致咀嚼器官和骨骼或牙齿发育异常。目的是评估儿童特发性肾病综合征中糖皮质激素剂量和治疗时间与牙颌畸形的发生频率和类型的相关性。
研究组由 31 名年龄在 5 至 17 岁之间、被诊断为特发性类固醇敏感性肾病综合征的患者和 33 名整体健康的儿童组成。研究包括牙列的临床评估、影像学诊断和统计分析。
研究组中 77.4%的患者被诊断为牙发育异常。发现牙齿数量异常、乳牙滞留和阻生牙、冠或根形状异常、釉质发育缺陷、牙髓结石和骨结构异常。统计分析显示，在无牙发育异常和有牙发育异常的患者中，糖皮质激素的平均治疗时间存在显著差异。
长期使用糖皮质激素治疗肾病综合征儿童会促进牙齿发育异常、牙髓钙化和骨组织代谢紊乱的发生。出于这个原因，类固醇敏感性肾病综合征患者应接受牙医的持续护理。
