: Children with nephrotic syndrome (NS) are prone to oral health issues due to immunosuppression and systemic inflammation, which may exacerbate their renal condition. The objective of this study was to evaluate the impact of a 12-year interdisciplinary collaboration between pediatric dentists and nephrologists on oral health in children with NS. : A retrospective analysis of 80 NS patients-40 assessed in 2012 and 40 in 2024-was conducted using caries indices (dmft/DMFT), Plaque Index, and Gingival Index. Statistical tests assessed differences between groups ( < 0.05). : The prevalence of active caries significantly decreased (50% vs. 78%; = 0.011), with fewer decayed permanent teeth (0.96 ± 1.56 vs. 2.66 ± 2.51; = 0.003) and improved oral hygiene (good hygiene in 52.5% vs. 30%; = 0.041) in the 2024 group. Gingivitis was less severe compared to 2012. : Long-term interdisciplinary care significantly improved oral health in children with NS. These improvements may contribute to reduced systemic inflammation and better overall disease control. Integrating dental care into NS management is recommended to support long-term outcomes.