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跨学科协作对肾病综合征患儿口腔健康的长期影响:一项12年回顾性研究

Long-Term Impact of Interdisciplinary Collaboration on Oral Health in Children with Nephrotic Syndrome: A 12-Year Retrospective Study.

作者信息

Piekoszewska-Ziętek Paula, Pańczyk-Tomaszewska Małgorzata, Olczak-Kowalczyk Dorota

机构信息

Department of Paediatric Dentistry, Medical University of Warsaw, 02-091 Warsaw, Poland.

Department of Paediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland.

出版信息

J Clin Med. 2025 Apr 15;14(8):2696. doi: 10.3390/jcm14082696.

DOI:10.3390/jcm14082696
PMID:40283525
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12027630/
Abstract

: Children with nephrotic syndrome (NS) are prone to oral health issues due to immunosuppression and systemic inflammation, which may exacerbate their renal condition. The objective of this study was to evaluate the impact of a 12-year interdisciplinary collaboration between pediatric dentists and nephrologists on oral health in children with NS. : A retrospective analysis of 80 NS patients-40 assessed in 2012 and 40 in 2024-was conducted using caries indices (dmft/DMFT), Plaque Index, and Gingival Index. Statistical tests assessed differences between groups ( < 0.05). : The prevalence of active caries significantly decreased (50% vs. 78%; = 0.011), with fewer decayed permanent teeth (0.96 ± 1.56 vs. 2.66 ± 2.51; = 0.003) and improved oral hygiene (good hygiene in 52.5% vs. 30%; = 0.041) in the 2024 group. Gingivitis was less severe compared to 2012. : Long-term interdisciplinary care significantly improved oral health in children with NS. These improvements may contribute to reduced systemic inflammation and better overall disease control. Integrating dental care into NS management is recommended to support long-term outcomes.

摘要

肾病综合征(NS)患儿由于免疫抑制和全身炎症,容易出现口腔健康问题,这可能会加重他们的肾脏病情。本研究的目的是评估儿科牙医和肾病科医生之间为期12年的跨学科合作对NS患儿口腔健康的影响。:使用龋病指数(dmft/DMFT)、菌斑指数和牙龈指数对80例NS患者进行回顾性分析——2012年评估40例,2024年评估40例。统计检验评估组间差异(<0.05)。:2024年组的活动性龋齿患病率显著降低(50%对78%;P=0.011),恒牙龋坏数量减少(0.96±1.56对2.66±2.51;P=0.003),口腔卫生状况改善(良好卫生状况从30%提高到52.5%;P=0.041)。与2012年相比,牙龈炎症状减轻。:长期跨学科护理显著改善了NS患儿的口腔健康。这些改善可能有助于减轻全身炎症,更好地控制整体疾病。建议将牙科护理纳入NS管理,以支持长期治疗效果。

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本文引用的文献

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Pediatr Nephrol. 2025 Jul;40(7):2287-2293. doi: 10.1007/s00467-025-06698-1. Epub 2025 Feb 4.
2
KIM-1, IL-18, and NGAL, in the Machine Learning Prediction of Kidney Injury among Children Undergoing Hematopoietic Stem Cell Transplantation-A Pilot Study.基于机器学习的儿童造血干细胞移植术后肾损伤预测模型:KIM-1、IL-18 和 NGAL 的初步研究
Int J Mol Sci. 2023 Oct 31;24(21):15791. doi: 10.3390/ijms242115791.
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The association between dental caries and steroid-sensitive nephrotic syndrome in children.儿童龋齿与类固醇敏感性肾病综合征的关系。
Pediatr Nephrol. 2024 Apr;39(4):1125-1133. doi: 10.1007/s00467-023-06167-7. Epub 2023 Oct 2.
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Childhood nephrotic syndrome.儿童肾病综合征。
Lancet. 2023 Sep 2;402(10404):809-824. doi: 10.1016/S0140-6736(23)01051-6.
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IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome.国际儿科肾病学会关于儿童激素敏感性肾病综合征诊断和治疗的临床实践建议。
Pediatr Nephrol. 2023 Mar;38(3):877-919. doi: 10.1007/s00467-022-05739-3. Epub 2022 Oct 21.
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Developmental Abnormalities of Teeth in Children With Nephrotic Syndrome.肾病综合征患儿牙齿发育异常。
Int Dent J. 2022 Aug;72(4):572-577. doi: 10.1016/j.identj.2021.11.014. Epub 2022 Mar 8.
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Prim Care. 2020 Dec;47(4):597-613. doi: 10.1016/j.pop.2020.08.002. Epub 2020 Sep 26.
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