Peterson H P, von Wangenheim K H, Feinendegen L E
Exp Hematol. 1986 Sep;14(8):776-81.
If radiation-induced reduction in the proliferative ability of bone marrow cells is due to a change in the age structure of stem cells, it might be measurable by an increase in the ratio of 7- to 12-day spleen colonies. This increase has not been detected at either three weeks or one year after 5 Gy gamma-irradiation. It was found, however, that diameters of colonies and weights of hemopoietic tissue per colony were reduced after both periods of recovery. Thus, slow colony growth may have masked a change in the stem cell age structure. It is concluded that injury persists in a proportion of stem cells that continues the production of progeny and may contribute to late effects. Persisting cellular injury, in modified form, may affect all mitotically active tissues.
如果辐射诱导的骨髓细胞增殖能力降低是由于干细胞年龄结构的变化所致，那么通过7至12天脾集落比例的增加可能可以检测到。在5 Gyγ射线照射后3周或1年时均未检测到这种增加。然而，发现两个恢复阶段后集落直径和每个集落造血组织重量均降低。因此，缓慢的集落生长可能掩盖了干细胞年龄结构的变化。得出的结论是，一部分干细胞中存在持续性损伤，这些干细胞继续产生子代，可能导致晚期效应。持续存在的细胞损伤以改变的形式可能影响所有有丝分裂活跃的组织。
