Gallagher Kathleen M E, Leick Mark B, Larson Rebecca C, Berger Trisha R, Katsis Katelin, Yam Jennifer Y, Maus Marcela V
Immune Monitoring Laboratory, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Clin Infect Dis. 2022 Aug 24;75(1):e869-e873. doi: 10.1093/cid/ciac201.
COVID-19 breakthrough cases among vaccinated individuals demonstrate the value of measuring long-term immunity to SARS-CoV-2 and its variants. We demonstrate that anti-spike T-cell responses and IgG antibody levels are maintained but decrease over time and are lower in BNT162b2- versus mRNA-1273-vaccinated individuals. T-cell responses to the variants are relatively unaffected.
接种疫苗个体中出现的新冠病毒突破性感染病例证明了测量对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)及其变体的长期免疫力的价值。我们证明,抗刺突T细胞反应和IgG抗体水平得以维持,但会随时间下降,并且在接种BNT162b2疫苗的个体中低于接种mRNA-1273疫苗的个体。T细胞对变体的反应相对未受影响。