Pan Ming, Bai Shao-Yuan, Ji Tian-Kai, Fan Yi-Min, Liu Dan-Dan, Yang Yi, Tao Jian-Ping, Huang Si-Yang
Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou, Jiangsu Province 225009, PR China.
Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou, Jiangsu Province 225009, PR China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, PR China.
Acta Trop. 2022 Jun;230:106394. doi: 10.1016/j.actatropica.2022.106394. Epub 2022 Mar 9.
Fasciolosis is a zoonotic disease as 600 million animals have been infected, and 180 million people are at risk of the infection in the world. Snail as the intermediate host of Fasciola is an essential and important factor in the transmission of fasciolosis, while its potential risk for transmission has not been studied. In this study, 3561 snails collected from large-scale regions of China were examined by nest-PCR method. A total of 345 snails were positive for Fasciola spp., with an overall prevalence of 9.7%. Prevalence in central and southern China, characterized by a subtropical monsoon climate, was relatively low (8.0%), while a high infection rate (36.9%) was found on the plateau area (altitude > 500 m). In combination with previous findings, the study showed a highly positive correlation between snails and animal infection in central and eastern China, thus indicating that infected snails could be an indispensable risk factor for fasciolosis transmission. Epidemiological surveillance of snails will help assess the risk of fasciolosis in humans or ruminants, which promotes future prevention of this zoonotic disease.
肝片吸虫病是一种人畜共患病，全球有6亿只动物受到感染，1.8亿人有感染风险。蜗牛作为肝片吸虫的中间宿主，是肝片吸虫病传播的一个重要因素，但其潜在传播风险尚未得到研究。在本研究中，采用巢式PCR方法对从中国广大地区采集的3561只蜗牛进行了检测。共有345只蜗牛肝片吸虫呈阳性，总体患病率为9.7%。中国中部和南部以亚热带季风气候为特征，患病率相对较低（8.0%），而在高原地区（海拔>500米）发现感染率较高（36.9%）。结合先前的研究结果，该研究表明中国中部和东部蜗牛与动物感染之间存在高度正相关，因此表明受感染的蜗牛可能是肝片吸虫病传播不可或缺的风险因素。对蜗牛进行流行病学监测将有助于评估人类或反刍动物感染肝片吸虫病的风险，从而促进对这种人畜共患病的未来预防。
