Department of Infection Disease, The First Affiliated Hospital of Dali University, Dali, Yunnan, China (mainland).
Jiangxi Provincial Key Laboratory of Medicine, Clinical Laboratory of The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Med Sci Monit. 2023 Oct 2;29:e940581. doi: 10.12659/MSM.940581.
BACKGROUND Human fascioliasis is an emerging zoonotic disease caused by the trematodes, or flatworms, Fasciola hepatica and Fasciola gigantica, also known as liver flukes. This retrospective study aimed to report the epidemiological findings in 95 cases of human fascioliasis in Dali, Yunnan Province, southwestern China, diagnosed between 2012 and 2021. MATERIAL AND METHODS The epidemiologic and clinical data of 95 patients diagnosed with human fascioliasis in Dali area from January 2012 to December 2021 were collected and retrospectively analyzed. The diagnosis of fascioliasis was based on the Chinese National Standard of Diagnosis of Fascioliasis (WS/T566-2017). RESULTS The mean age of patients was 38.54±15.68 years, and there were more female patients than male (61.05% vs 38.95%). The high-incidence seasons were identified as summer and autumn. The patients with human fascioliasis lived in pastoral areas or were infected F. gigantica by consuming contaminated vegetables or water containing metacercaria. Meanwhile, human fascioliasis was diagnosed by positive serologic tests (1: 640), and Fasciola eggs (144-180×73-96 μm) were detected in stool samples of 6 patients. The most common clinical features were abdominal pain (70.53%), accompanied by elevated eosinophils in 89.5% of these patients. Antiparasitic treatment with triclabendazole at 10 mg/kg/day for 2 days led to symptom relief in all patients. CONCLUSIONS The findings from this observational epidemiological study have highlighted the importance of recognizing, diagnosing, and managing fascioliasis, which is an emerging zoonosis associated with increased human proximity to plant-eating domestic and farmed animals.
人体片形吸虫病是一种由吸虫（扁形动物）肝片形吸虫和巨片形吸虫引起的新兴人畜共患疾病，也称为肝吸虫病。本回顾性研究旨在报告 2012 年至 2021 年间在中国云南省大理地区诊断的 95 例人体片形吸虫病的流行病学发现。
收集并回顾性分析了 2012 年 1 月至 2021 年 12 月期间在大理地区诊断为人体片形吸虫病的 95 例患者的流行病学和临床数据。片形吸虫病的诊断基于《人体片形吸虫病诊断国家标准》（WS/T566-2017）。
患者的平均年龄为 38.54±15.68 岁，女性患者多于男性（61.05%比 38.95%）。高发季节为夏季和秋季。感染人体片形吸虫病的患者生活在牧区，或因食用受污染的蔬菜或含有囊蚴的水而感染巨片形吸虫。同时，通过阳性血清学试验（1:640）和 6 例患者粪便中检测到的片形吸虫卵（144-180×73-96μm）诊断为人体片形吸虫病。最常见的临床特征是腹痛（70.53%），同时这些患者中有 89.5%的患者嗜酸性粒细胞升高。用 10mg/kg/天的三氯苯达唑治疗 2 天可使所有患者的症状得到缓解。
这项观察性流行病学研究的结果强调了认识、诊断和管理与人类与食草家畜和农场动物的接触增加有关的新兴人畜共患病——片形吸虫病的重要性。
