Hu Guanjie, Ge Honglin, Yang Kun, Liu Dongming, Liu Yong, Jiang Zijuan, Hu Xiao, Xiao Chaoyong, Zou Yuanjie, Liu Hongyi, Hu Xinhua, Chen Jiu
Department of Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Department of Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Neuroscience. 2022 May 10;490:79-88. doi: 10.1016/j.neuroscience.2022.03.006. Epub 2022 Mar 9.
Contralateral regions play critical role in functional compensation in glioma patients. Voxel-mirrored homotopic connectivity (VMHC) characterizes the intrinsic functional connectivity (FC) of the brain, considered to have a regional functional basis. We aimed to investigate the alterations of brain regional function and VMHC in patients with frontal glioma, and further investigated the correlation between these alterations and cognition. We enrolled patients with frontal glioma and matched healthy controls (HC). We chose degree centrality (DC), regional homogeneity (ReHo), and VMHC to investigate the alterations of regional function and intrinsic FC in patients. Furthermore, partial correlation analyses were conducted to explore the relationship between imaging functional indicators and cognitions. Compared with HC, patients showed decreased static VMHC within right and left middle frontal gyrus (MFG.R, MFG.L), left superior frontal gyrus (SFG.L), right precuneus (PCUN.R), and left precuneus (PCUN.L), decreased static DC within left cingulate gyrus (CG.L), right superior frontal gyrus (SFG.R), and right postcentral gyrus (POCG.R), decreased static ReHo within CG.L, decreased dynamic ReHo within right inferior parietal lobule (IPL.R), but increased dynamic VMHC (dVMHC) within PCUN.R and PCUN.L. Furthermore, values of decreased VMHC within MFG.R, decreased DC within CG.L, decreased ReHo within CG.L, and increased dVMHC within PCUN.R were significantly positively correlated with cognitive functions. We preliminarily confirmed glioma causes regional dysfunction and disturbs long-distance FC, and long-distance FC showed strong instability in patients with frontal glioma. Meanwhile, the correlation analyses indicated directions for cognitive protection in patients with frontal glioma.
对侧区域在胶质瘤患者的功能代偿中起关键作用。体素镜像同伦连接性（VMHC）表征大脑的内在功能连接性（FC），被认为具有区域功能基础。我们旨在研究额叶胶质瘤患者脑区功能和VMHC的改变，并进一步探讨这些改变与认知之间的相关性。我们纳入了额叶胶质瘤患者和匹配的健康对照（HC）。我们选择度中心性（DC）、局部一致性（ReHo）和VMHC来研究患者区域功能和内在FC的改变。此外，进行偏相关分析以探索影像功能指标与认知之间的关系。与HC相比，患者右侧和左侧额中回（MFG.R、MFG.L）、左侧额上回（SFG.L）、右侧楔前叶（PCUN.R）和左侧楔前叶（PCUN.L）的静态VMHC降低，左侧扣带回（CG.L）、右侧额上回（SFG.R）和右侧中央后回（POCG.R）的静态DC降低，CG.L内的静态ReHo降低，右侧顶下小叶（IPL.R）内的动态ReHo降低，但PCUN.R和PCUN.L内的动态VMHC（dVMHC）增加。此外，MFG.R内VMHC降低、CG.L内DC降低、CG.L内ReHo降低以及PCUN.R内dVMHC增加的值与认知功能显著正相关。我们初步证实胶质瘤会导致区域功能障碍并扰乱长距离FC，并且长距离FC在额叶胶质瘤患者中表现出强烈的不稳定性。同时，相关分析为额叶胶质瘤患者的认知保护指明了方向。
