核糖体图谱分析：探索新冠病毒未知领域的有效方法
Ribosome Profiling: A Useful Approach to Discover Hidden Corners of SARS-CoV-2.
作者信息
Zandi Milad, Behboudi Emad, Zeinali Parisa, Soltani Saber, Shojaei Mohammad Reza
机构信息
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Email:
Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
出版信息
Cell J. 2022 Feb;24(2):103-104. doi: 10.22074/cellj.2022.8387.
Abstract
Following SARS-CoV-2 China epidemic in the December 2019, researches have attended to the genome of novel coronavirus. Hidden corners of SARS-CoV-2, maybe a shiny way to discover its pathogenicity and virulence. To design therapeutic agents, it is critical to map the complete repertoire of viral-translated proteins. Ribosome profiling is considered as a snapshot of all active ribosomes in a cell at a specific time point.
摘要
2019年12月中国出现新型冠状病毒肺炎疫情后，研究人员开始关注新型冠状病毒的基因组。新型冠状病毒的隐蔽之处，或许是发现其致病性和毒力的一条线索。为了设计治疗药物，描绘病毒翻译蛋白的完整清单至关重要。核糖体分析被认为是特定时间点细胞内所有活跃核糖体的一张快照。
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