Nakamoto Masahiko, Noguchi Moe, Nishiguchi Akihiro, Mano João F, Matsusaki Michiya, Akashi Mitsuru
Division of Applied Chemistry, Osaka University, Graduate School of Engineering, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, Campus Universitario de Santiago, 3810-193, Aveiro, Portugal.
Mater Today Bio. 2022 Mar 1;14:100225. doi: 10.1016/j.mtbio.2022.100225. eCollection 2022 Mar.
We report a highly stretchable hydrogel based on the crosslinking structure between calcium cations and alendronates (ALN) conjugated with poly-γ-glutamate (γ-PGA), a typical biodegradable polymer. γ-PGA with ALN (γ-PGA-ALN) forms the hydrogel in the aqueous solution containing CaCl. The hydrogel shows 2000% of stretchability and reversible stretching without failure at a strain of 250%. The fracture strain and stress are tunable by varying the concentration of either γ-PGA-ALN or CaCl, indicating the importance of fine-tuning of the density of the cross-linkage to control the mechanical properties of the hydrogel. We believe the biodegradable polymer based highly stretchable hydrogel has potential for use in various fields such as tissue engineering.
我们报道了一种基于钙阳离子与与聚γ-谷氨酸（γ-PGA，一种典型的可生物降解聚合物）共轭的阿仑膦酸盐（ALN）之间交联结构的高拉伸性水凝胶。带有ALN的γ-PGA（γ-PGA-ALN）在含有CaCl的水溶液中形成水凝胶。该水凝胶显示出2000%的拉伸性，并且在250%的应变下可进行可逆拉伸而不失效。通过改变γ-PGA-ALN或CaCl的浓度，断裂应变和应力是可调的，这表明微调交联密度对于控制水凝胶的机械性能很重要。我们相信这种基于可生物降解聚合物的高拉伸性水凝胶在组织工程等各个领域具有应用潜力。
