Al-Rashidi Hanan E
Medical Laboratory Technology Department, Faculty of Applied Medical Sciences, Taibah University, Saudi Arabia.
Saudi J Biol Sci. 2022 Mar;29(3):1628-1643. doi: 10.1016/j.sjbs.2021.10.068. Epub 2021 Oct 30.
Human gut is colonized by numerous microorganisms, in which bacteria present the highest proportion of this colonization that live in a symbiotic relationship with the host. This microbial collection is commonly known as the microbiota. The gut microbiota can mediate gut epithelial and immune cells interaction through vitamins synthesis or metabolic products. The microbiota plays a vital role in growth and development of the main components of human's adaptive and innate immune system, while the immune system regulates host-microbe symbiosis. On the other hand, negative alteration in gut microbiota composition or gut dysbiosis, can disturb immune responses. This review highlights the gut microbiota-immune system cross-talk in both eubiosis and dysbiosis.
人类肠道中定植着大量微生物,其中细菌在这种定植中所占比例最高,它们与宿主处于共生关系。这种微生物群落通常被称为微生物群。肠道微生物群可以通过维生素合成或代谢产物介导肠道上皮细胞与免疫细胞的相互作用。微生物群在人类适应性和先天性免疫系统主要成分的生长和发育中起着至关重要的作用,而免疫系统则调节宿主与微生物的共生关系。另一方面,肠道微生物群组成的负面改变或肠道生态失调会干扰免疫反应。本综述重点介绍了肠道微生物群与免疫系统在正常共生和生态失调状态下的相互作用。