一种通过动员牙龈间充质干细胞归巢促进口腔伤口愈合的创新化合物。
An innovative compound that promotes oral wound healing via mobilizing gingival mesenchymal stem cell homing.
作者信息
Yang Lei, Song Yue, Jiao Yao, Liu Siyan, Liu Yi, Guo Lijia, Liu Yitong
机构信息
Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, No.9 Fanjiacun Road, Fengtai District, Beijing, 100070, PR China.
Department of Orthodontics (WangFuJing Campus), School of Stomatology, Capital Medical University, No.11 Scylla alley, Dongcheng District, PR China.
出版信息
Biochem Biophys Rep. 2025 Jul 15;43:102154. doi: 10.1016/j.bbrep.2025.102154. eCollection 2025 Sep.
Oral wound healing is a complex biological process involving inflammation, proliferation, and tissue remodeling. Gingival mesenchymal stem cells (GMSCs) play a crucial role in this process due to their regenerative potential and immunomodulatory properties. This study investigated whether Purpurolide C (PC), a fungal-derived bioactive compound, could promote oral wound healing by promoting the migratory ability of GMSCs. In vitro, PC enhanced GMSC migration, pluripotency, and osteogenic differentiation. In vivo, a mouse palatal soft tissue defect model demonstrated that PC significantly accelerated wound closure and increased GMSC recruitment to the wound site. Furthermore, 16S rRNA sequencing revealed that PC administration did not disrupt gut microbiota homeostasis. These findings suggest that PC is a promising therapeutic agent for enhancing oral wound healing, paving the way for potential clinical applications in regenerative medicine.
口腔伤口愈合是一个复杂的生物学过程，涉及炎症、增殖和组织重塑。牙龈间充质干细胞（GMSCs）由于其再生潜力和免疫调节特性，在这一过程中发挥着关键作用。本研究调查了一种真菌衍生的生物活性化合物Purpurolide C（PC）是否能通过促进GMSCs的迁移能力来促进口腔伤口愈合。在体外，PC增强了GMSCs的迁移、多能性和成骨分化。在体内，小鼠腭部软组织缺损模型表明，PC显著加速了伤口闭合，并增加了GMSCs向伤口部位的募集。此外，16S rRNA测序显示，给予PC不会破坏肠道微生物群的稳态。这些发现表明，PC是一种有前途的治疗剂，可促进口腔伤口愈合，为再生医学的潜在临床应用铺平了道路。
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