Asadi Parvin, Khodamoradi Elahe, Dinari Mohammad
Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Res Pharm Sci. 2022 Jan 15;17(2):143-152. doi: 10.4103/1735-5362.335173. eCollection 2022 Apr.
Layered double hydroxides (LDHs) as inorganic materials are being used in controlled release and drug delivery systems. These materials are more stable than conventional drug carriers. In this investigation, Mg/Al-ascorbic acid (ASA) LDH nanohybrid was synthesized by ultrasonic-assisted co-deposition techniques.
In this study, Mg/Al-LDH to adsorption of ASA anions from the alkaline solution was assembled by a facile coprecipitation technique. During this process, ultrasonic irradiation was used to increase the rate of ion exchange between LDH and ASA. The intercalated-layered structure was characterized by FT-IR spectroscopy, XRD, thermogravimetric analysis, field emission SEM, and TEM. ASA releasing from Mg/Al-ASA LDH nanohybrid was carried out in incubation sodium carbonate solution (0.5 M) at 35 °C using UV-Vis absorbance analysis at λ = 265 nm.
FINDINGS/RESULTS: The used techniques confirmed the structure of Mg/Al-LDH and indicated successful intercalation of ASA into the interlayer galleries of the LDH host. The obtained results also have shown that Mg/Al-ASA LDH nanohybrid was generated with an average diameter size of 25 nm and narrow size distribution. Analysis of the release profiles using several kinetic models suggested that the first-order rate model is the most appropriate for describing the release of ASA from Mg/Al-LDH which means the amount of drug released is proportional to the amount of remaining drug in the matrix. Thus, the amount of activity released tends to decrease in function of time.
The results showed that LDHs are good host materials to preserve the biomolecule and modify its release rate and bioavailability.
层状双氢氧化物（LDHs）作为无机材料正被应用于控释和药物递送系统。这些材料比传统药物载体更稳定。在本研究中，通过超声辅助共沉淀技术合成了镁铝 - 抗坏血酸（ASA）LDH纳米杂化物。
在本研究中，采用简便的共沉淀技术将镁铝 - LDH组装用于从碱性溶液中吸附ASA阴离子。在此过程中，使用超声辐射来提高LDH与ASA之间的离子交换速率。通过傅里叶变换红外光谱（FT - IR）、X射线衍射（XRD）、热重分析、场发射扫描电子显微镜（SEM）和透射电子显微镜（TEM）对插层结构进行表征。在35℃下，于0.5M碳酸钠孵育溶液中，利用紫外可见吸光度分析（波长λ = 265nm）对镁铝 - ASA LDH纳米杂化物中的ASA释放情况进行研究。
所采用的技术证实了镁铝 - LDH的结构，并表明ASA成功插层进入LDH主体的层间通道。所得结果还表明，生成的镁铝 - ASA LDH纳米杂化物的平均直径尺寸为25nm，且尺寸分布狭窄。使用几种动力学模型对释放曲线进行分析表明，一级速率模型最适合描述ASA从镁铝 - LDH中的释放，这意味着释放的药物量与基质中剩余的药物量成正比。因此，释放的活性量随时间趋于减少。
结果表明，LDHs是保存生物分子并改变其释放速率和生物利用度的良好主体材料。
