Zhang Hanqun, Zhang Yun, Xia Tingting, Lu Liang, Luo Min, Chen Yanping, Liu Yuncong, Li Yong
Department of Oncology, Guizhou Provincial People's Hospital, Guizhou, China.
Department of Pathology, Guizhou Provincial People's Hospital, Guizhou, China.
Front Cell Dev Biol. 2022 Feb 24;10:818416. doi: 10.3389/fcell.2022.818416. eCollection 2022.
Keratins are a group of proteins that can constitute intermediate fibers. It is a component of the cytoskeleton and plays an important role in cell protection and structural support. Keratin 17, a Type I keratin, is a multifunctional protein that regulates a variety of biological processes, including cell growth, proliferation, migration, apoptosis and signal transduction. Abnormal expression of KRT17 is associated with a variety of diseases, such as skin diseases. In recent years, studies have shown that KRT17 is abnormally expressed in a variety of malignant tumours, such as lung cancer, cervical cancer, oral squamous cell carcinoma and sarcoma. These abnormal expressions are related to the occurrence, development and prognosis of malignant tumors. In this review, we summarized the expression patterns of KRT17 in a variety of malignant tumours, the role of KRT17 in the development and prognosis of different malignant tumors and its molecular mechanisms. We also discuss the potential clinical application of KRT17 as a valuable therapeutic target.
角蛋白是一组能够构成中间纤维的蛋白质。它是细胞骨架的组成部分，在细胞保护和结构支撑中发挥重要作用。角蛋白17属于I型角蛋白，是一种多功能蛋白质，可调节多种生物学过程，包括细胞生长、增殖、迁移、凋亡和信号转导。KRT17的异常表达与多种疾病相关，如皮肤病。近年来，研究表明KRT17在多种恶性肿瘤中异常表达，如肺癌、宫颈癌、口腔鳞状细胞癌和肉瘤。这些异常表达与恶性肿瘤的发生、发展和预后有关。在本综述中，我们总结了KRT17在多种恶性肿瘤中的表达模式、KRT17在不同恶性肿瘤发生发展和预后中的作用及其分子机制。我们还讨论了KRT17作为有价值的治疗靶点的潜在临床应用。
