Qi Xiang, Northridge Mary E, Hu Mengyao, Wu Bei
Rory Meyers College of Nursing, New York University, 433 First Avenue, Room 520, New York, NY 10010, USA.
Grossman School of Medicine, New York University, New York 10016, USA.
Aging Health Res. 2022 Mar;2(1):100064. doi: 10.1016/j.ahr.2022.100064. Epub 2022 Mar 5.
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the importance of understanding the underlying conditions that lead to COVID-19. Oral health has systemic implications in the maintenance of a healthy state. This study aimed to summarize evidence on the prevalence of oral health conditions in participants with COVID-19 and assess the associations between oral health conditions and COVID-19 related outcomes.
Article searches were conducted in five databases and the gray literature from December 1, 2019 to March 1, 2021. Studies that reported oral health conditions for participants with COVID-19 and/or examined associations between oral health and COVID-19 were included.
We identified 15 articles that encompassed 5,377 participants with COVID-19 from 10 countries. Dry mouth was the most common oral health condition reported (41.0%), followed by oral lesions (38.8%), orofacial pain (18.3%), and periodontal symptoms (11.7%). Based on the pooled odds ratios (ORs), periodontal symptoms were not associated with COVID-19 positivity (OR = 1.1; 95% confidence intervals [CI], 0.73-1.65) or mortality (OR = 2.71; 95% CI, 0.64-11.51), but were associated with COVID-19 severity (OR = 3.18; 95% CI, 1.81-5.58).
Oral health conditions are common in participants with COVID-19 and should be considered in both the onset and progression of this disease. Knowledge in this area is still limited, and the quality of the data extracted was low. Further longitudinal studies are needed to ascertain whether oral health conditions are a consequence of infection with SARS-CoV-2 or whether they predate infection and are risk factors for COVID-19.
2019年冠状病毒病（COVID-19）大流行凸显了了解导致COVID-19的潜在状况的重要性。口腔健康对维持健康状态具有全身影响。本研究旨在总结COVID-19患者口腔健康状况患病率的证据，并评估口腔健康状况与COVID-19相关结局之间的关联。
于2019年12月1日至2021年3月1日在五个数据库及灰色文献中进行文献检索。纳入报告COVID-19患者口腔健康状况和/或研究口腔健康与COVID-19之间关联的研究。
我们确定了15篇文章，涵盖来自10个国家的5377名COVID-19患者。报告的最常见口腔健康状况是口干（41.0%），其次是口腔病变（38.8%）、口面部疼痛（18.3%）和牙周症状（11.7%）。根据合并比值比（OR），牙周症状与COVID-19阳性（OR = 1.1；95%置信区间[CI]，0.73 - 1.65）或死亡率（OR = 2.71；95%CI，0.64 - 11.51）无关，但与COVID-19严重程度相关（OR = 3.18；95%CI，1.81 - 5.58）。
COVID-19患者中口腔健康状况很常见，在该疾病的发病和进展过程中均应予以考虑。该领域的知识仍然有限，提取的数据质量较低。需要进一步开展纵向研究，以确定口腔健康状况是感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的结果，还是在感染之前就已存在并是COVID-19的危险因素。
