Favia Gianfranco, Tempesta Angela, Barile Giuseppe, Brienza Nicola, Capodiferro Saverio, Vestito Maria Concetta, Crudele Lucilla, Procacci Vito, Ingravallo Giuseppe, Maiorano Eugenio, Limongelli Luisa
Odontostomatology Unit, Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy.
Covid-19 Intensive Care Unit, Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy.
J Clin Med. 2021 Feb 13;10(4):757. doi: 10.3390/jcm10040757.
The aim of this study is to report on the oral lesions detected in 123 patients diagnosed at the University Hospital of Bari from October 2020 to December 2020, focusing on the correlation of clinical and pathological features in order to purpose a new classification.
General and specialistic anamnesis were achieved and oral examination was performed. The following data were collected: age/gender, general symptoms and form of Covid-19, presence and features of taste disorders, day of appearance of the oral lesions, type and features of oral lesions and day of beginning of therapies. If ulcerative lesions did not heal, biopsy was performed.
Many types of oral lesions were found and classified into four groups considering the timing of appearance and the start of the therapies. Early lesions in the initial stages of Covid-19 before the start of therapies was observed in 65.9% of the patients. In the histopathological analysis of four early lesions, thrombosis of small and middle size vessels was always noticed with necrosis of superficial tissues.
The presence of oral lesions in early stages of Covid-19 could represent an initial sign of peripheral thrombosis, a warning sign of possible evolution to severe illness. This suggests that anticoagulant therapies should start as soon as possible.
本研究的目的是报告2020年10月至2020年12月在巴里大学医院确诊的123例患者中检测到的口腔病变，重点关注临床和病理特征的相关性，以便提出一种新的分类方法。
进行了一般和专科病史采集并进行了口腔检查。收集了以下数据：年龄/性别、新冠病毒病的一般症状和形式、味觉障碍的存在及特征、口腔病变出现的日期、口腔病变的类型及特征以及治疗开始的日期。如果溃疡性病变未愈合，则进行活检。
发现了多种类型的口腔病变，并根据出现时间和治疗开始情况分为四组。65.9%的患者在新冠病毒病初始阶段且治疗开始前出现早期病变。在对四个早期病变的组织病理学分析中，总是注意到中小血管血栓形成并伴有浅表组织坏死。
新冠病毒病早期出现口腔病变可能代表外周血栓形成的初始迹象，是可能发展为重症的警示信号。这表明抗凝治疗应尽早开始。
