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基底样鳞状细胞癌

Basaloid squamous cell carcinoma.

作者信息

Santhosh Manikandan V Jai, Krishna P Sai, Makesh Raj L S, Sekhar Prasanna

机构信息

Department of Oral and Maxillofacial Pathology, Tagore Dental College and Hospital, Chennai, Tamil Nadu, India.

出版信息

J Oral Maxillofac Pathol. 2021 Sep-Dec;25(3):533-536. doi: 10.4103/jomfp.jomfp_382_21. Epub 2022 Jan 11.

DOI:10.4103/jomfp.jomfp_382_21
PMID:35281164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8859593/
Abstract

Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma characterized by a conglomerate of clinically aggressive course and disparate histopathological features. It is frequently seen in upper aerodigestive tract area. Histopathologically, it is biphasic and composed of two types of tumor cells, namely basaloid and squamous cells. Tumor markers, namely, BerEp4, epithelial membrane antigen and p53 are used in this case to differentiate from similar tumors which impersonate BSCC histologically but differ prognostically. We report a case of BSCC in a 48-year-old female patient, involving the lateral border of the tongue with an exhaustive picture of its histological and immunohistochemical appearance.

摘要

基底样鳞状细胞癌（BSCC）是鳞状细胞癌的一种罕见变体，其特征是临床病程侵袭性强且组织病理学特征各异。它常见于上呼吸消化道区域。组织病理学上，它是双相的，由两种肿瘤细胞组成，即基底样细胞和鳞状细胞。在这种情况下，使用肿瘤标志物，即BerEp4、上皮膜抗原和p53来与组织学上类似BSCC但预后不同的肿瘤进行鉴别。我们报告一例48岁女性患者的BSCC病例，病变累及舌外侧缘，并对其组织学和免疫组化表现进行了详尽描述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f31/8859593/7bb887a07a43/JOMFP-25-533-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f31/8859593/53c239d1b3c0/JOMFP-25-533-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f31/8859593/96bbc4d0f092/JOMFP-25-533-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f31/8859593/184dc1dc051a/JOMFP-25-533-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f31/8859593/54273e518fda/JOMFP-25-533-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f31/8859593/7bb887a07a43/JOMFP-25-533-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f31/8859593/53c239d1b3c0/JOMFP-25-533-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f31/8859593/96bbc4d0f092/JOMFP-25-533-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f31/8859593/184dc1dc051a/JOMFP-25-533-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f31/8859593/54273e518fda/JOMFP-25-533-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f31/8859593/7bb887a07a43/JOMFP-25-533-g005.jpg

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本文引用的文献

1
Clinical and epidemiological analysis of basosquamous carcinoma: results of the multicenter study.基底鳞状细胞癌的临床和流行病学分析：多中心研究结果。
Sci Rep. 2020 Oct 28;10(1):18475. doi: 10.1038/s41598-020-72732-x.
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Small cell neuroendocrine carcinoma of the orbit presenting as an orbital abscess in a young female.一名年轻女性眼眶出现眶内脓肿，经诊断为眼眶小细胞神经内分泌癌。
Saudi J Ophthalmol. 2019 Jul-Sep;33(3):308-311. doi: 10.1016/j.sjopt.2018.07.003. Epub 2018 Jul 27.
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BerEp4, cytokeratin 14, and cytokeratin 17 immunohistochemical staining aid in differentiation of basaloid squamous cell carcinoma from basal cell carcinoma with squamous metaplasia.
Immunohistochemical Expression of Bcl-2, E-cadherin, CD34 and CD105 in Basaloid Squamous Cell Carcinoma - An Study.
基底样鳞状细胞癌中Bcl-2、E-钙黏蛋白、CD34和CD105的免疫组化表达——一项研究
Ann Maxillofac Surg. 2024 Jul-Dec;14(2):206-211. doi: 10.4103/ams.ams_50_24. Epub 2024 Sep 9.
BerEp4、细胞角蛋白 14 和细胞角蛋白 17 的免疫组织化学染色有助于区分基底样鳞状细胞癌和具有鳞状化生的基底细胞癌。
Arch Pathol Lab Med. 2013 Nov;137(11):1591-8. doi: 10.5858/arpa.2012-0424-OA.
4
Expression of cytokeratin subtypes: MMP-9, p53, and αSMA to differentiate basaloid squamous cell carcinoma from other basaloid tumors of the oral cavity.细胞角蛋白亚型、基质金属蛋白酶-9（MMP-9）、p53和α平滑肌肌动蛋白（αSMA）的表达用于鉴别口腔基底样鳞状细胞癌与其他口腔基底样肿瘤。
Appl Immunohistochem Mol Morphol. 2013 Oct;21(5):431-43. doi: 10.1097/PAI.0b013e31827c00e1.
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Basaloid squamous cell carcinoma of the head and neck: a clinicopathological and follow-up study of 40 cases and review of the literature.头颈部基底样鳞状细胞癌：40例临床病理及随访研究并文献复习
Head Neck Pathol. 2008 Jun;2(2):83-91. doi: 10.1007/s12105-008-0045-6. Epub 2008 Mar 21.
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Basaloid squamous cell carcinoma of the mandible: report of two cases.下颌骨基底样鳞状细胞癌：2例报告
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Immunohistochemistry in ocular carcinomas.眼癌中的免疫组织化学
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Histopathology. 2000 Sep;37(3):218-23. doi: 10.1046/j.1365-2559.2000.00999.x.
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Basaloid-squamous carcinoma of the tongue, hypopharynx, and larynx: report of 10 cases.舌、下咽和喉的基底样鳞状细胞癌：10例报告。
Hum Pathol. 1986 Nov;17(11):1158-66. doi: 10.1016/s0046-8177(86)80422-1.
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Adenoid cystic carcinoma of the salivary glands: an immunohistochemical analysis.唾液腺腺样囊性癌：一项免疫组织化学分析
Oral Surg Oral Med Oral Pathol. 1988 Mar;65(3):316-26. doi: 10.1016/0030-4220(88)90116-8.