Zakh Rami, Churkin Alexander, Bietsch William, Lachiany Menachem, Cotler Scott J, Ploss Alexander, Dahari Harel, Barash Danny
Department of Computer Science, Ben-Gurion University, Beer-Sheva 8410501, Israel.
Department of Software Engineering, Sami Shamoon College of Engineering, Beer-Sheva 8410501, Israel.
Mathematics (Basel). 2021;9(24). doi: 10.3390/math9243323. Epub 2021 Dec 20.
Hepatitis delta virus (HDV) is an infectious subviral agent that can only propagate in people infected with hepatitis B virus (HBV). HDV/HBV infection is considered to be the most severe form of chronic viral hepatitis. In this contribution, a mathematical model for the interplay between HDV and HBV under anti-HDV treatment is presented. Previous models were not designed to account for the observation that HBV rises when HDV declines with HDV-specific therapy. In the simple model presented here, HDV and HBV kinetics are coupled, giving rise to an improved viral kinetic model that simulates the early interplay of HDV and HBV during anti-HDV therapy.
丁型肝炎病毒（HDV）是一种传染性亚病毒因子，仅能在感染乙型肝炎病毒（HBV）的人群中传播。HDV/HBV感染被认为是慢性病毒性肝炎最严重的形式。在本论文中，我们提出了一个在抗HDV治疗下HDV与HBV相互作用的数学模型。先前的模型并未考虑到在HDV特异性治疗中HDV下降时HBV会上升这一观察结果。在此提出的简单模型中，HDV和HBV的动力学相互耦合，从而产生了一个改进的病毒动力学模型，该模型可模拟抗HDV治疗期间HDV和HBV的早期相互作用。
