Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai, China.
Department of Gynecology, The Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Front Endocrinol (Lausanne). 2022 Feb 23;13:808508. doi: 10.3389/fendo.2022.808508. eCollection 2022.
PCOS is defined as a kind of endocrine and metabolic disorder which affects females at reproductive ages, is becoming much more common, nowadays. Microbiomes are known as microorganisms that inhabit the body to play a vital role in human health. In recent years, several basic and clinical studies have tried to investigate the correlation between the reproductive health/disorder and microbiomes (gut microbiomes and vaginal microbiomes). However, the mechanism is still unclear. In this review, we reviewed the relationship between PCOS and microbiomes, including gut/vaginal microbiomes compositions in PCOS, mechanism of microbiomes and PCOS, and then collectively focused on the recent findings on the influence of microbiomes on the novel insight regarding the therapeutic strategies for PCOS in the future clinical practice.
多囊卵巢综合征（PCOS）定义为一种影响育龄女性的内分泌和代谢紊乱疾病，如今变得越来越普遍。微生物组是指栖息在人体中对人类健康起着至关重要作用的微生物。近年来，一些基础和临床研究试图探讨生殖健康/障碍与微生物组（肠道微生物组和阴道微生物组）之间的相关性。然而，其机制尚不清楚。在这篇综述中，我们回顾了 PCOS 与微生物组之间的关系，包括 PCOS 中肠道/阴道微生物组的组成、微生物组与 PCOS 的作用机制，然后集中讨论了微生物组对未来临床实践中 PCOS 治疗策略的新见解的影响的最新发现。
