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急性心肌梗死与新型冠状病毒肺炎病理生理关联的关键基因

The Key Genes Underlying Pathophysiology Correlation Between the Acute Myocardial Infarction and COVID-19.

作者信息

You Hongjun, Zhao Qianqian, Dong Mengya

机构信息

Department of Cardiovascular Medicine, Shaanxi Provincial People's Hospital, Xi'an, 710068, Shaanxi, People's Republic of China.

Department of Clinical Immunology, The First Affiliated Hospital, Air Force Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.

出版信息

Int J Gen Med. 2022 Mar 4;15:2479-2490. doi: 10.2147/IJGM.S354885. eCollection 2022.

DOI:10.2147/IJGM.S354885
PMID:35282650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8904943/
Abstract

INTRODUCTION

Accumulating evidences disclose that COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has a marked effect on acute myocardial infarction (AMI). Nevertheless, the underlying pathophysiology correlation between the AMI and COVID-19 remains vague.

MATERIALS AND METHODS

Bioinformatics analyses of the altered transcriptional profiling of peripheral blood mononuclear cells (PBMCs) in patients with AMI and COVID-19 were implemented, including identification of differentially expressed genes and common genes between AMI and COVID-19, protein-protein interactions, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses, TF-genes and miRNA coregulatory networks, to explore their biological functions and potential roles in the pathogenesis of COVID-19-related AMI.

CONCLUSION

Our bioinformatic analyses of gene expression profiling of PBMCs in patients with AMI and COVID-19 provide us with a unique view regarding underlying pathophysiology correlation between the two vital diseases.

摘要

引言

越来越多的证据表明，由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）对急性心肌梗死（AMI）有显著影响。然而，AMI与COVID-19之间潜在的病理生理相关性仍不明确。

材料与方法

对AMI和COVID-19患者外周血单个核细胞（PBMC）转录谱改变进行生物信息学分析，包括鉴定AMI和COVID-19之间的差异表达基因和共同基因、蛋白质-蛋白质相互作用、基因本体论和京都基因与基因组百科全书通路分析、转录因子-基因和微小RNA共调控网络，以探索它们在COVID-19相关AMI发病机制中的生物学功能和潜在作用。

结论

我们对AMI和COVID-19患者PBMC基因表达谱的生物信息学分析，为我们提供了关于这两种重大疾病潜在病理生理相关性的独特视角。

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本文引用的文献

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J Thromb Haemost. 2021 Nov;19(11):2652-2658. doi: 10.1111/jth.15509. Epub 2021 Sep 3.
2
A Potent Leukocyte Transmigration Blocker: GT-73 Showed a Protective Effect against LPS-Induced ARDS in Mice.一种强效白细胞迁移抑制剂：GT-73 对 LPS 诱导的小鼠 ARDS 具有保护作用。
Molecules. 2021 Jul 29;26(15):4583. doi: 10.3390/molecules26154583.
3
A protein interactions map of multiple organ systems associated with COVID-19 disease.
Biomolecules. 2023 May 11;13(5):816. doi: 10.3390/biom13050816.
4
Exploring Potential Biomarkers and Molecular Mechanisms of Ischemic Cardiomyopathy and COVID-19 Comorbidity Based on Bioinformatics and Systems Biology.基于生物信息学和系统生物学探索缺血性心肌病与 COVID-19 合并症的潜在生物标志物和分子机制。
Int J Mol Sci. 2023 Mar 30;24(7):6511. doi: 10.3390/ijms24076511.
与新冠病毒疾病相关的多器官系统蛋白质相互作用图谱。
Genomics Inform. 2021 Jun;19(2):e14. doi: 10.5808/gi.20078. Epub 2021 Jun 30.
4
Multilevel systems biology analysis of lung transcriptomics data identifies key miRNAs and potential miRNA target genes for SARS-CoV-2 infection.肺转录组学数据的多层次系统生物学分析鉴定了 SARS-CoV-2 感染的关键 miRNAs 和潜在的 miRNA 靶基因。
Comput Biol Med. 2021 Aug;135:104570. doi: 10.1016/j.compbiomed.2021.104570. Epub 2021 Jun 12.
5
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.SARS-CoV-2 介导的代谢和自噬失调揭示了针对宿主的抗病毒药物。
Nat Commun. 2021 Jun 21;12(1):3818. doi: 10.1038/s41467-021-24007-w.
6
Type 1 Kounis Syndrome Induced by Inactivated SARS-COV-2 Vaccine.1 型 Kounis 综合征由灭活 SARS-CoV-2 疫苗引起。
J Emerg Med. 2021 Oct;61(4):e71-e76. doi: 10.1016/j.jemermed.2021.04.018. Epub 2021 May 7.
7
Biomarkers for Prognosis and Treatment Response in COVID-19 Patients.用于 COVID-19 患者预后和治疗反应的生物标志物。
Ann Lab Med. 2021 Nov 1;41(6):540-548. doi: 10.3343/alm.2021.41.6.540.
8
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9
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Brief Bioinform. 2021 Sep 2;22(5). doi: 10.1093/bib/bbab120.