Shi Xiaomeng, Qiu Hongyu
Center for Molecular and Translational Medicine, Institute of Biomedical Sciences, Georgia State University, Atlanta, GA, United States.
Front Physiol. 2022 Feb 25;13:831829. doi: 10.3389/fphys.2022.831829. eCollection 2022.
Cardiac function highly relies on sufficient energy supply. Perturbations in myocardial energy metabolism play a causative role in cardiac pathogenesis. Accumulating evidence has suggested that modifications of cardiac metabolism are also an essential part of the adaptive responses to various physiological conditions in the heart to meet specific energy needs. The review highlighted some new studies on basic myocardial energy substrate metabolism and updated recent findings regarding cardiac metabolic remodeling and their associated mechanisms under physiological conditions, including exercise and cardiac development. Studying basic metabolic profiles in the heart in these conditions can contribute to understanding the significance of metabolic regulation in the heart during physiological adaption and gaining further insights into the maladaptive metabolic changes associated with cardiac pathogenesis, thus opening up new avenues to exploring novel therapeutic strategies in cardiac diseases.
心脏功能高度依赖充足的能量供应。心肌能量代谢紊乱在心脏发病机制中起致病作用。越来越多的证据表明，心脏代谢的改变也是心脏对各种生理状况作出适应性反应以满足特定能量需求的重要组成部分。这篇综述重点介绍了一些关于心肌能量底物基础代谢的新研究，并更新了有关生理条件下（包括运动和心脏发育）心脏代谢重塑及其相关机制的最新发现。研究这些条件下心脏的基础代谢概况有助于理解生理适应过程中心脏代谢调节的重要性，并进一步深入了解与心脏发病机制相关的适应性不良代谢变化，从而为探索心脏病的新型治疗策略开辟新途径。
