1970 - 1979年英格兰和威尔士克雅氏病的回顾性研究。II：流行病学。
A retrospective study of Creutzfeldt-Jakob disease in England and Wales 1970-1979. II: Epidemiology.
作者信息
Will R G, Matthews W B, Smith P G, Hudson C
出版信息
J Neurol Neurosurg Psychiatry. 1986 Jul;49(7):749-55. doi: 10.1136/jnnp.49.7.749.
Abstract
A comprehensive search yielded 121 confirmed cases of Creutzfeldt-Jakob disease who died in England and Wales in the decade 1970-1979, 31 probable cases and 10 possible cases. Descriptive epidemiological data are presented. The average annual incidence was 0.3 cases/million. An unexpected female excess was found. There was no evidence of space-time clustering of cases and no associations with occupation or past medical treatment were apparent. There was statistically significant variation in incidence rates in different parts of the country but no relationship was discovered between incidence and population density.
摘要
一项全面搜索发现，在1970年至1979年的十年间，英格兰和威尔士有121例确诊克雅氏病死亡病例、31例疑似病例和10例可能病例。文中呈现了描述性流行病学数据。年平均发病率为每百万人口0.3例。发现女性发病率意外偏高。没有证据表明病例存在时空聚集现象，也未发现与职业或既往治疗存在关联。该国不同地区的发病率存在统计学上的显著差异，但未发现发病率与人口密度之间存在关系。
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