Yong Christl S K, Maniam Ethan Jian-Hui, Chang Cheryl W L, Lai Jonathan Yexian, Ho Cyrus Su Hui
Department of Psychological Medicine, National University Health System, Singapore, Singapore.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Front Neurol. 2023 Aug 7;14:1239576. doi: 10.3389/fneur.2023.1239576. eCollection 2023.
Creutzfeldt-Jakob Disease (CJD) is a rare, rapidly progressive, and fatal neurodegenerative disorder. We describe a man whose initial manifestations of CJD occurred shortly after contracting Coronavirus disease 2019 (COVID-19). He first developed anxiety and short-term memory loss a few weeks after a mild COVID-19 infection. He subsequently developed parkinsonism, eventually progressed to akinetic mutism, and passed away 5 months after symptom onset. This case highlights a potential temporal relationship between COVID-19 infection and the onset of neurodegenerative symptoms. Microglia and astrocytes in the central nervous system (CNS) and 'S1' spike proteins on SARS-CoV-2 are potential mediators in neuroinflammation and neurodegeneration.
克雅氏病（CJD）是一种罕见的、快速进展的致命性神经退行性疾病。我们描述了一名男子，其克雅氏病的最初表现出现在感染2019冠状病毒病（COVID-19）后不久。他在轻度COVID-19感染几周后首先出现焦虑和短期记忆丧失。随后他出现帕金森综合征，最终发展为运动不能性缄默症，并在症状出现后5个月去世。该病例突出了COVID-19感染与神经退行性症状发作之间潜在的时间关系。中枢神经系统（CNS）中的小胶质细胞和星形胶质细胞以及严重急性呼吸综合征冠状病毒2（SARS-CoV-2）上的“S1”刺突蛋白是神经炎症和神经退行性变的潜在介质。
