Akalu Tadesse Yirga, Aynalem Yared Asmare, Shiferaw Wondimeneh Shibabaw, Merkeb Alamneh Yoseph, Getnet Asmamaw, Abebaw Abtie, Atnaf Aytenew, Abate Abebe, Tilahun Melkamu, Kassie Bekalu, Aschale Yibeltal
College of Health Science, Debre Markos University, Debre Markos, Ethiopia.
College of Health Science, Debre Birhan University, Debre Birhan, Ethiopia.
SAGE Open Med. 2022 Mar 8;10:20503121221082447. doi: 10.1177/20503121221082447. eCollection 2022.
The aim of this systematic review and meta-analysis is designed to assess the pooled prevalence and determine risk factors of intestinal parasitic infections among people living with HIV/AIDS on anti-retroviral therapy in Ethiopia.
International databases: PubMed, Web of Science, Cochrane Library, Scopus, PsycINFO, African Journals Online, and Google Scholar were systematically searched. Publication bias was determined using the funnel plot and Egger's regression tests. Heterogeneity between the studies included in this review was checked by statistic. The DerSimonian and Laird random-effects model was applied to estimate the pooled effect size. Sub-group, meta-regression, and sensitivity analysis were conducted. Overall, meta-analysis was done using Stata version 14 statistical software.
Twenty-seven studies with 8946 individuals were included, the estimated pooled prevalence of intestinal parasitic infections among people living with HIV/AIDS on anti-retroviral therapy was 40.24% (95% confidence interval = 33.8-46.6). Based on sub-group analysis, the highest prevalence was observed in the Tigray region 45.7% (95% confidence interval = 7.9-83.5), followed by Oromia region 42.2% (95% confidence interval = 28.8-55.6). Availability of latrine (odds ratio = 26.6, 95% confidence interval = 2.8-15.8), presence of animals at home (odds ratio = 2.7, 95% confidence interval = 1.2-5.8), and source of drinking water (odds ratio = 3.2, 95% confidence interval = 1.3-7.5) were significantly associated with intestinal parasitic infections.
These findings indicated that the prevalence of intestinal parasites among people living with HIV/AIDS was high in Ethiopia.
本系统评价和荟萃分析旨在评估埃塞俄比亚接受抗逆转录病毒治疗的艾滋病毒/艾滋病感染者肠道寄生虫感染的合并患病率，并确定其危险因素。
系统检索国际数据库：PubMed、科学网、考克兰图书馆、Scopus、PsycINFO、非洲期刊在线和谷歌学术。使用漏斗图和埃格回归检验确定发表偏倚。通过统计量检查本评价纳入研究之间的异质性。应用DerSimonian和Laird随机效应模型估计合并效应量。进行亚组分析、荟萃回归分析和敏感性分析。总体而言，使用Stata 14统计软件进行荟萃分析。
纳入了27项研究，共8946名个体，接受抗逆转录病毒治疗的艾滋病毒/艾滋病感染者肠道寄生虫感染的估计合并患病率为40.24%（95%置信区间=33.8-46.6）。基于亚组分析，提格雷地区患病率最高，为45.7%（95%置信区间=7.9-83.5），其次是奥罗米亚地区，为42.2%（95%置信区间=28.8-55.6）。有厕所（优势比=26.6，95%置信区间=2.8-15.8）、家中有动物（优势比=2.7，95%置信区间=1.2-5.8）和饮用水源（优势比=3.2，95%置信区间=1.3-7.5）与肠道寄生虫感染显著相关。
这些发现表明，埃塞俄比亚艾滋病毒/艾滋病感染者肠道寄生虫感染率很高。
