Mur Jaka, Agrež Vid, Petelin Jaka, Petkovšek Rok
University of Ljubljana, Faculty of Mechanical Engineering, Aškerčeva 6, SI-1000 Ljubljana, Slovenia.
Biomed Opt Express. 2022 Jan 31;13(2):1061-1069. doi: 10.1364/BOE.449814. eCollection 2022 Feb 1.
Precise excitation of cavitation is a promising mechanism for microsurgery procedures and targeted drug delivery enhancement. The underlying phenomenon of interest, jetting behaviour of oscillating cavitation bubbles, occurs due to near-surface interactions between the boundary, liquid, and bubble. Within this study we measured boundary effects on the cavitation bubble dynamics and morphology, with an emphasis on observation and measurement of jetting behaviour near tissue-phantom biointerfaces. An important mechanism of boundary poration has been observed using time-resolved optical microscopy and explained for different tissue-phantom surface densities and Young's modulus. Below a critical distance to the boundary, around γ = 1.0, the resulting jets penetrated the tissue-phantom, resulting in highly localized few micrometer diameter jets.
精确激发空化是一种很有前景的显微手术和增强靶向药物递送的机制。感兴趣的潜在现象，即振荡空化气泡的喷射行为，是由于边界、液体和气泡之间的近表面相互作用而产生的。在本研究中，我们测量了边界对空化气泡动力学和形态的影响，重点是观察和测量组织-仿体生物界面附近的喷射行为。利用时间分辨光学显微镜观察到了边界穿孔的一个重要机制，并针对不同的组织-仿体表面密度和杨氏模量进行了解释。在距边界的临界距离以下，约γ = 1.0时，产生的射流穿透组织-仿体，形成高度局部化的直径为几微米的射流。
