Paranthaman Mariappan Parans, Peroutka-Bigus Nathan, Larsen Kristina R, Phadke Kruttika S, Summers Tina, Theodore Merlin, Hensley Dale K, Levine Alan M, Lee Richard J, Bellaire Bryan H
Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA.
Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Mater Today Adv. 2022 Jun;14:100228. doi: 10.1016/j.mtadv.2022.100228. Epub 2022 Mar 8.
The application of antiviral coatings to masks and respirators is a potential mitigating step toward reducing viral transmission during the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic. The use of appropriate masks, social distancing, and vaccines is the immediate solution for limiting the viral spread and protecting people from this virus. N95 respirator masks are effective in filtering the virus particles, but they cannot kill or deactivate the virus. We report a possible approach to deactivating SARS-CoV-2 by applying an antimicrobial coating (Goldshield 75) to masks and respirators, rendering them suitable for repeated use. Masks coated with Goldshield 75 demonstrated continuous inactivation of the Alpha and Beta variants of the SARS-CoV-2 over a 3-day period and no loss of inactivation when stored at temperatures at 50 °C.
在口罩和呼吸器上应用抗病毒涂层是在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行期间减少病毒传播的一个潜在缓解措施。使用合适的口罩、保持社交距离和接种疫苗是限制病毒传播和保护人们免受这种病毒侵害的直接解决办法。N95呼吸器口罩在过滤病毒颗粒方面有效，但它们不能杀死或灭活病毒。我们报告了一种可能的方法，即通过在口罩和呼吸器上应用抗菌涂层（Goldshield 75）来灭活SARS-CoV-2，使其适合重复使用。涂有Goldshield 75的口罩在3天内对SARS-CoV-2的阿尔法和贝塔变体表现出持续的灭活效果，并且在50°C的温度下储存时灭活效果没有损失。
