Liu Yang, Liu Jianying, Shi Pei-Yong
Institute of Infectious Disease, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, USA.
Zoonoses. 2022;2(1). doi: 10.15212/zoonoses-2022-0001. Epub 2022 Feb 8.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused global destruction since its emergence in late 2019. Over the past two years, the virus has continuously evolved in human host, leading to emergence of variants with changed viral transmission, disease severity, and evasion of immunity. Although vaccines have been developed for the coronavirus disease 2019 (COVID-19) at an unprecedently pace, the variants have constantly posed threats to the effectiveness of the approved vaccines. In this short communication, we review the key variants and discuss their implications in viral replication, transmission, and immune evasion.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）自2019年末出现以来已造成全球破坏。在过去两年中，该病毒在人类宿主中不断进化，导致出现了病毒传播、疾病严重程度和免疫逃逸发生变化的变种。尽管针对2019冠状病毒病（COVID-19）的疫苗以前所未有的速度研发出来，但这些变种不断对已获批疫苗的有效性构成威胁。在这篇简短的通讯中，我们综述了关键变种，并讨论它们在病毒复制、传播和免疫逃逸方面的影响。
