Institute of Life Course and Medical Sciences, Faculty of Health and Life Sciences, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool, L7 8TX, UK.
University of Liverpool Small Animal Teaching Hospital, University of Liverpool, Leahurst Campus, Chester High Road, Neston, CH64 7TE, UK.
J Small Anim Pract. 2022 Oct;63(10):721-738. doi: 10.1111/jsap.13495. Epub 2022 Mar 14.
Canine osteoarthritis is a significant cause of pain in many dogs and can therefore compromise animal welfare. As the understanding of the biology and pain mechanisms underpinning osteoarthritis grows, so do the number of treatments available to manage it. Over the last decade, there have been a number of advances in the pharmaceutical treatment options available for dogs with osteoarthritis, as well as an increasing number of clinical trials investigating the efficacy of pre-existing treatments. This review aims to examine the current evidence behind pharmaceutical treatment options for canine osteoarthritis, including non-steroidal anti-inflammatory drugs, piprants, monoclonal antibodies, adjunctive analgesics, structure modifying osteoarthritis drugs and regenerative therapies.
犬骨关节炎是许多犬只疼痛的一个重要原因，因此会损害动物福利。随着对骨关节炎基础生物学和疼痛机制的理解不断深入，可供管理该病的治疗方法的数量也在不断增加。在过去十年中，针对骨关节炎犬的药物治疗选择有了一些进展，同时也有越来越多的临床试验在调查现有治疗方法的疗效。本综述旨在检查犬骨关节炎药物治疗选择的现有证据，包括非甾体抗炎药、吡嗪酰胺、单克隆抗体、辅助镇痛药、结构修饰性骨关节炎药物和再生疗法。
