Divisão de Medicina Veterinária, Guarda Nacional Republicana (GNR), Rua Presidente Arriaga, 9, 1200-771, Lisbon, Portugal.
MED - Mediterranean Institute for Agriculture, Environment and Development, Instituto de Investigação e Formação Avançada, Universidade de Évora, Pólo da Mitra, Ap. 94, 7006-554, Évora, Portugal.
BMC Vet Res. 2021 Jun 5;17(1):207. doi: 10.1186/s12917-021-02913-x.
BACKGROUND: Osteoarthritis (OA) is the most commonly diagnosed joint disease in companion animals, and hip OA is commonly diagnosed in the canine population. The use of platelet-rich plasma has gained increasing interest for the treatment of musculoskeletal conditions in companion animals. To evaluate the effect of the intra-articular administration of platelet-rich plasma in police working dogs with bilateral hip OA compared to a control group, twenty dogs were assigned to a control group (CG, n = 10) or treatment group (PG, n = 10), using the statistical analysis software. PG received two intra-articular administrations of platelet-rich plasma, 14 days apart, while CG received an intra-articular administration of saline, in the same moments. Response to treatment was determined with the Canine Brief Pain Inventory, Liverpool Osteoarthritis in Dogs, Canine Orthopedic Index, and Hudson Visual Analogue Scale, before treatment, + 8, + 15, + 30, + 60, + 90, + 120, 150, and + 180 days after initial treatment. Kaplan-Meier estimators were conducted and compared with the log-rank test. Cox proportional hazard regression analysis was performed to determine treatment survival, p < 0.05. RESULTS: The sample comprised 20 animals of both sexes (male n = 12, female n = 8), with a mean age of 8.4 ± 2.4 years and a bodyweight of 31.5 ± 5.7 kg. Joints were classified as moderate (13) and severe (7) according to the Orthopedic Foundation for Animals grading scheme. No differences were found between groups at the initial evaluation. Better results with the majority of scores were observed in the PG, in some cases lasting up to the last evaluation moment. Kaplan-Meier estimators showed that PG produced longer periods with better results in all scores compared to CG. Treatment was the covariate influencing all scores in the Cox regression analysis. OFA hip score also influenced two dimensions of the Canine Orthopedic Index. CONCLUSION: The intra-articular administration of platelet-rich plasma can improve pain and functional scores of police working dogs with bilateral hip OA, compared with a control group. Its effects lasted for significantly longer periods, and treatment was the main covariate affecting the improvements observed.
背景：骨关节炎（OA）是伴侣动物中最常见的关节疾病，髋关节 OA 在犬类中也很常见。富血小板血浆的应用越来越受到伴侣动物肌肉骨骼疾病治疗的关注。为了评估与对照组相比，关节内注射富血小板血浆对双侧髋关节 OA 的警犬的治疗效果，使用统计分析软件将 20 只犬分为对照组（CG，n=10）和治疗组（PG，n=10）。PG 接受了两次关节内注射富血小板血浆，间隔 14 天，而 CG 在同一时间接受了关节内注射生理盐水。在治疗前、初次治疗后 +8、+15、+30、+60、+90、+120、150 和+180 天，使用犬Brief 疼痛量表、利物浦犬关节炎、犬骨科指数和哈德逊视觉模拟量表来确定治疗反应。进行 Kaplan-Meier 估计并与对数秩检验进行比较。进行 Cox 比例风险回归分析以确定治疗存活率，p<0.05。 结果：样本包括 20 只雌雄动物（雄性 n=12，雌性 n=8），平均年龄为 8.4±2.4 岁，体重为 31.5±5.7kg。根据动物骨科基金会的分级方案，关节被分类为中度（13 个）和重度（7 个）。在初始评估时，两组之间没有差异。PG 组的大多数评分结果更好，在某些情况下，这种情况持续到最后一次评估。Kaplan-Meier 估计显示，PG 在所有评分中产生的更好结果的时间比 CG 更长。在 Cox 回归分析中，治疗是影响所有评分的协变量。OFA 髋关节评分也影响犬骨科指数的两个维度。 结论：与对照组相比，关节内注射富血小板血浆可以改善双侧髋关节 OA 警犬的疼痛和功能评分。其效果持续时间明显更长，治疗是影响观察到的改善的主要协变量。
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