Department of Dermatology, University of Pisa, Pisa, Italy.
Department of Clinical and Experimental Medicine, Section of Statistics, University of Pisa, Pisa, Italy.
Exp Dermatol. 2022 Jun;31(6):956-961. doi: 10.1111/exd.14563. Epub 2022 Mar 31.
There is a strong interaction between the immunological and nervous system in the skin. Lesions that are physically disfiguring and chronically relapsing have a high impact on quality of life (QoL) and can result in the emergence of psychiatric disorders. The literature data confirm a higher prevalence of psychiatric disorders in patients with psoriasis, hidradenitis suppurativa (HS) and atopic dermatitis (AD), but such data are compromised by low-quality evidence due to methodological heterogeneity.
The primary aim was to analyse the prevalence of psychiatric comorbidities in a group of psoriasis, AD and HS patients compared with a control group. The secondary aims were to evaluate the impact of psychiatric comorbidities on the disease development, severity, flare-ups and QoL.
A total of 59 cases and 64 controls were included.
Generalized anxiety disorder and depressive disorder with anxious distress were found to be risk factors for AD. Age, smoking and substance-related disorder showed a specific association with HS. Major depressive disorder showed a specific association with dermatology life quality index (DLQI) and all the above disease flare-ups.
Atopic dermatitis, psoriasis and HS are associated with psychiatric disorders. A psychodermatological approach improves outcomes in terms of QoL, disease flare-ups and long-term management.
皮肤的免疫系统和神经系统之间存在着强烈的相互作用。身体畸形和慢性复发的病变对生活质量（QoL）有很大影响，并可能导致精神障碍的出现。文献数据证实，银屑病、化脓性汗腺炎（HS）和特应性皮炎（AD）患者的精神障碍患病率较高，但由于方法学的异质性，此类数据的证据质量较低。
分析一组银屑病、AD 和 HS 患者与对照组相比，精神共病的患病率。次要目的是评估精神共病对疾病发展、严重程度、发作和 QoL 的影响。
共纳入 59 例病例和 64 例对照。
广泛性焦虑症和伴有焦虑苦恼的抑郁症被认为是 AD 的危险因素。年龄、吸烟和物质相关障碍与 HS 有特定的关联。重度抑郁症与皮肤病生活质量指数（DLQI）和所有上述疾病发作有特定的关联。
特应性皮炎、银屑病和 HS 与精神障碍有关。精神皮肤病学方法可改善 QoL、疾病发作和长期管理的结果。
