Spitzer Carsten, Buchholz Ines, Lübke Laura, Wülfing Clara, Meier Katharina, Kokolakis Georgios, Niebel Dennis, Mann Caroline, Karoglan Ante, Emmert Steffen, Thiem Alexander
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Rostock, Germany.
EuroQol Group, Rotterdam, The Netherlands.
Acta Derm Venereol. 2025 May 19;105:adv42794. doi: 10.2340/actadv.v105.42794.
Health-related quality of life (HRQoL) is reduced in atopic dermatitis and psoriasis. Several factors impact HRQoL including sociodemographic and skin disease-related characteristics, health behaviours, cardiometabolic comorbidities, and psychological conditions. However, their differential and unique effects on HRQoL are not well studied. In this cross-sectional online survey, adult patients with atopic dermatitis (n = 155) or psoriasis (n = 246) provided data on features of their respective skin diseases, health behaviours, and cardiometabolic comorbidities. Validated self-report measures assessed HRQoL, psychopathology (Patient Health Questionnaire-4), and stress (Perceived Stress Scale). Linear regression analyses were used to determine key predictors of HRQoL. In atopic dermatitis, linear regression analyses revealed that self-rated disease severity (Patient-Oriented Eczema Measure), anxiety, and stress were significant predictors of the Dermatology Life Quality Index (DLQI), explaining 59% of the variance. In psoriasis, disease severity (Psoriasis Symptoms and Signs Diary) and depression significantly predicted DLQI, with an explained variance of 57%. Health behaviours and cardiometabolic comorbidities did not impact DLQI scores. While skin disease severity is the most important determinant of HRQoL, stress and anxiety are important in atopic dermatitis, whereas depression is relevant in psoriasis. These findings hold implications for both clinical practice and research.
特应性皮炎和银屑病患者的健康相关生活质量（HRQoL）会降低。多种因素会影响HRQoL，包括社会人口统计学特征、与皮肤病相关的特征、健康行为、心血管代谢合并症以及心理状况。然而，它们对HRQoL的差异和独特影响尚未得到充分研究。在这项横断面在线调查中，成年特应性皮炎患者（n = 155）或银屑病患者（n = 246）提供了各自皮肤病特征、健康行为和心血管代谢合并症的数据。通过经过验证的自我报告测量方法评估HRQoL、精神病理学（患者健康问卷 - 4）和压力（感知压力量表）。使用线性回归分析来确定HRQoL的关键预测因素。在特应性皮炎中，线性回归分析显示，自我评定的疾病严重程度（患者导向性湿疹测量）、焦虑和压力是皮肤病生活质量指数（DLQI）的显著预测因素，解释了59%的方差。在银屑病中，疾病严重程度（银屑病症状和体征日记）和抑郁显著预测了DLQI，解释方差为57%。健康行为和心血管代谢合并症并未影响DLQI评分。虽然皮肤病严重程度是HRQoL的最重要决定因素，但压力和焦虑在特应性皮炎中很重要，而抑郁在银屑病中具有相关性。这些发现对临床实践和研究都具有启示意义。
