PEDEGO Research Unit, University of Oulu, Oulu, Finland; Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.
Unit of General Practice, Oulu University Hospital, Oulu, Finland; Center for Life Course Epidemiology and Systems Medicine, University of Oulu, Oulu, Finland.
J Invest Dermatol. 2018 Jan;138(1):46-51. doi: 10.1016/j.jid.2017.06.020. Epub 2017 Jul 21.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of hair follicles that is associated with various comorbidities. To further clarify the associations between HS and psychiatric disorders, we conducted a nationwide retrospective study that included 4,381 patients with HS, and 39,554 with psoriasis and 43,248 with melanocytic nevi as controls. Patient data were obtained from the statutory Finnish Care Register for Health Care. The incidence of HS was 3.0/100,000 persons/year. At least one psychiatric diagnosis was found in 24.1% of the patients with HS compared with 19.1% of the patients with psoriasis (odds ratio 1.34; 95% confidence interval 1.24-1.46) and 13.5% of those with melanocytic nevi (odds ratio 2.04; confidence interval 1.88-2.22). Every mental disorder examined was significantly more frequent in HS than in the two other groups. Mental disorders were more common in women than in men with HS and psoriasis. The main finding of our study is that patients with HS have a higher risk of mental disorders than patients with psoriasis. Additionally, this study reveals that HS is associated with both schizophrenia (odds ratio 1.57; confidence interval 1.24-1.98) and bipolar disorder (odds ratio 1.81; confidence interval 1.47-2.23), findings that to our knowledge have not been reported previously.
化脓性汗腺炎（HS）是一种与多种合并症相关的慢性毛囊炎症性皮肤病。为了进一步阐明 HS 与精神障碍之间的关联，我们进行了一项全国性回顾性研究，纳入了 4381 例 HS 患者，以及 39554 例银屑病患者和 43248 例黑色素痣患者作为对照。患者数据来自法定的芬兰医疗保健登记处。HS 的发病率为 3.0/100,000 人/年。与银屑病患者（比值比 1.34；95%置信区间 1.24-1.46）和黑色素痣患者（比值比 2.04；置信区间 1.88-2.22）相比，至少有一个精神科诊断的 HS 患者占 24.1%。在 HS 患者中，所有检查的精神障碍都明显比在另外两组中更常见。HS 患者中，女性的精神障碍比男性更常见，且比银屑病患者更常见。我们研究的主要发现是，HS 患者患精神障碍的风险高于银屑病患者。此外，这项研究表明，HS 与精神分裂症（比值比 1.57；置信区间 1.24-1.98）和双相障碍（比值比 1.81；置信区间 1.47-2.23）均相关，据我们所知，这些发现以前尚未报道过。
