Morselli Marco, Dieci Giorgio
Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 23/A, 43124 Parma, Italy.
Biochem Soc Trans. 2022 Apr 29;50(2):723-736. doi: 10.1042/BST20210860.
Recent investigations on the non-protein-coding transcriptome of human cells have revealed previously hidden layers of gene regulation relying on regulatory non-protein-coding (nc) RNAs, including the widespread ncRNA-dependent regulation of epigenetic chromatin states and of mRNA translation and stability. However, despite its centrality, the epigenetic regulation of ncRNA genes has received relatively little attention. In this mini-review, we attempt to provide a synthetic account of recent literature suggesting an unexpected complexity in chromatin-dependent regulation of ncRNA gene transcription by the three human nuclear RNA polymerases. Emerging common features, like the heterogeneity of chromatin states within ncRNA multigene families and their influence on 3D genome organization, point to unexplored issues whose investigation could lead to a better understanding of the whole human epigenomic network.
近期对人类细胞非蛋白质编码转录组的研究揭示了依赖调控性非蛋白质编码（nc）RNA的基因调控中先前隐藏的层面，包括对表观遗传染色质状态以及mRNA翻译和稳定性的广泛ncRNA依赖性调控。然而，尽管ncRNA基因的表观遗传调控处于核心地位，但受到的关注相对较少。在这篇小型综述中，我们试图综合近期文献，揭示人类三种核RNA聚合酶对ncRNA基因转录的染色质依赖性调控存在意想不到的复杂性。新出现的共同特征，如ncRNA多基因家族内染色质状态的异质性及其对三维基因组组织的影响，指向了尚未探索的问题，对这些问题的研究可能有助于更好地理解整个人类表观基因组网络。
