Department of Pediatrics, Sheng Jing Hospital of China Medical University, Shenyang, China.
Pediatr Res. 2024 Aug;96(3):632-642. doi: 10.1038/s41390-024-03167-7. Epub 2024 Apr 3.
While perinatal medicine advancements have bolstered survival outcomes for premature infants, bronchopulmonary dysplasia (BPD) continues to threaten their long-term health. Gene-environment interactions, mediated by epigenetic modifications such as DNA methylation, histone modification, and non-coding RNA regulation, take center stage in BPD pathogenesis. Recent discoveries link methylation variations across biological pathways with BPD. Also, the potential reversibility of histone modifications fuels new treatment avenues. The review also highlights the promise of utilizing mesenchymal stem cells and their exosomes as BPD therapies, given their ability to modulate non-coding RNA, opening novel research and intervention possibilities. IMPACT: The complexity and universality of epigenetic modifications in the occurrence and development of bronchopulmonary dysplasia were thoroughly discussed. Both molecular and cellular mechanisms contribute to the diverse nature of epigenetic changes, suggesting the need for deeper biochemical techniques to explore these molecular alterations. The utilization of innovative cell-specific drug delivery methods like exosomes and extracellular vesicles holds promise in achieving precise epigenetic regulation.
虽然围产医学的进步提高了早产儿的存活率，但支气管肺发育不良（BPD）仍然威胁着他们的长期健康。基因-环境相互作用，通过表观遗传修饰如 DNA 甲基化、组蛋白修饰和非编码 RNA 调控，在 BPD 的发病机制中占据中心地位。最近的发现将生物途径中的甲基化变化与 BPD 联系起来。此外，组蛋白修饰的潜在可逆性为新的治疗方法提供了动力。该综述还强调了利用间充质干细胞及其外泌体作为 BPD 治疗方法的前景，因为它们能够调节非编码 RNA，为新的研究和干预提供了可能性。
本文深入讨论了表观遗传修饰在支气管肺发育不良发生和发展中的复杂性和普遍性。分子和细胞机制都促成了表观遗传变化的多样性，这表明需要更深入的生化技术来探索这些分子变化。利用创新的细胞特异性药物输送方法，如外泌体和细胞外囊泡，有望实现精确的表观遗传调控。
