Association of Polymorphisms in Estrogen Receptor Genes (1 and 2) with Osteoporosis and Fracture-Involvement of Comorbidities and Epistasis.

Single-nucleotide polymorphisms (SNPs) in the 1/2 genes play a role in osteoporosis (OP). Our objective was to determine associations of polymorphisms in genes with OP and fracture, SNP-SNP interactions, and involvement of comorbidities. We analyzed 170 Mexican osteoporotic women (FNOP), 173 with hip fracture (HFx), and 210 controls. The SNPs, 1 rs2234693CC, rs851982CC and rs1999805AA, were associated with reduced OP risk (odds ratios [ORs] = 0.35, 0.40 and 0.32, respectively;  < 0.05); rs2234693CC was associated with reduced fracture risk (OR = 0.24;  < 0.05). The obese/overweight carriers of rs9340799GG had a lower OP (OR = 0.15,  = 0.016) and fracture (OR = 0.12,  = 0.0057) risk. The rs9479055AA and rs3020404AA hypertensive carriers had a higher OP risk (OR = 5.96,  = 0.032; and OR = 5.29,  = 0.02, respectively). In addition, rs3020404AA had a higher risk of fracture (OR = 4.90,  = 0.045). The rs2228480GG hypertensive carriers had a higher risk of fracture (OR = 6.22,  = 0.0038). We found a synergic relation between the 1 rs3020331 and rs1999805 in femoral neck OP and HFx. The rs2234693 (II) and rs9340799 (I) polymorphisms are associated with a high risk forming a haplotype. The epistasis analysis suggests the contribution of both genes (1/2) to the risk of OP and fracture. Epistasis and involvement of obesity and hypertension lead to a significant modification of the risk.