University Medical Center Utrecht, Utrecht, Netherlands.
HUB Organoids, Utrecht, Netherlands.
J Exp Med. 2022 Apr 4;219(4). doi: 10.1084/jem.20220121. Epub 2022 Mar 14.
Tissue-resident memory T cells (TRM cells) reside in the epithelium and contribute to the first line defense against invading pathogens. Snyder et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212059) now report that clonally expanded, recipient T cells persist as TRM cells in human lung allografts despite intensive immunosuppression. Their persistence may contribute to chronic allograft dysfunction.
组织驻留记忆 T 细胞 (TRM 细胞) 存在于上皮组织中，有助于抵御入侵病原体的第一道防线。Snyder 等人 (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212059) 现在报告说，尽管进行了强化免疫抑制，受体 T 细胞仍作为 TRM 细胞在人肺移植物中持续存在，并且呈克隆扩增状态。它们的持续存在可能导致慢性移植物功能障碍。
