磷脂酰肌醇脂质依赖的 Kir2.2 门控结构与功能的相关性。
Correlation between structure and function in phosphatidylinositol lipid-dependent Kir2.2 gating.
机构信息
Laboratory of Molecular Neurobiology and Biophysics, HHMI, The Rockefeller University, New York, NY ,10065.
出版信息
Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2114046119. doi: 10.1073/pnas.2114046119. Epub 2022 Mar 14.
Abstract
SignificancePhosphatidylinositol 4,5-bisphosphate (PI(4,5)P) levels regulate cell membrane voltage by gluing two halves of a K channel together and opening the pore. PI(4)P competes with this process. Because both of these lipids are relatively abundant in the plasma membrane and are directly interconvertible through the action of specific enzymes, they may function together to regulate channel activity.
摘要
意义磷脂酰肌醇 4,5-二磷酸 (PI(4,5)P) 水平通过将 K 通道的两个半部分粘在一起并打开孔来调节细胞膜电压。PI(4)P 与此过程竞争。由于这两种脂质在质膜中相对丰富，并且可以通过特定酶的作用直接相互转化，因此它们可能共同发挥作用以调节通道活性。
Zotero 插件