National Medical College, Birgunj, Nepal.
Narayani Sub-Regional Hospital, Birgunj, Nepal.
Arch Womens Ment Health. 2022 Jun;25(3):671-674. doi: 10.1007/s00737-022-01221-z. Epub 2022 Mar 14.
Olanzapine is widely used during pregnancy to manage mood and psychotic disorders with overall beneficial effects. There have been past reports of olanzapine exposure during early pregnancy and clubfoot in two newborns from India and Israel. We report a woman in Nepal diagnosed with schizophrenia and treated with olanzapine throughout the pregnancy delivering a baby boy with congenital talipes equinovarus deformity. Like in many other low-income settings, pregnancy was unplanned, and pre-conception counselling was not done. Research in mice has revealed the negative effects of olanzapine on bone development. Further reports would strengthen this potential association between exposure to olanzapine in the first trimester and the occurrence of clubfoot in the baby.
奥氮平在怀孕期间被广泛用于治疗情绪和精神障碍，整体效果良好。过去有报道称，在印度和以色列的两名新生儿中，母亲在怀孕早期接触过奥氮平，导致出现了先天性马蹄内翻足。我们报告了一位尼泊尔妇女被诊断为精神分裂症，并在整个怀孕期间接受奥氮平治疗，生下了一名患有先天性马蹄内翻足畸形的男婴。与许多其他低收入环境一样，此次怀孕是意外的，没有进行孕前咨询。在老鼠身上的研究表明，奥氮平对骨骼发育有负面影响。进一步的报告将加强这种奥氮平在怀孕早期暴露与婴儿先天性马蹄内翻足之间的潜在关联。
