Chen Bi-Hong, Du Yi-Dan, Shu Wei
Shenzhen Grubbs Institute, Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, 518055, Guangdong, P. R. China.
Angew Chem Int Ed Engl. 2022 Jun 7;61(23):e202200773. doi: 10.1002/anie.202200773. Epub 2022 Apr 5.
Direct alkylation of the C-H bond arenes in a selective manner is a long-standing challenge. Herein, a metal-free photocatalytic regioselective C-H alkylation method for electron-rich arenes with both activated and unactivated alkenes was developed. The reaction tolerates a wide range of aromatic rings with diverse substitution patterns, as well as terminal and internal alkenes, providing a general and straightforward metal-free method for C-C bond formation from inert C-H bonds. Moreover, alkynes are also compatible to give the C-H vinylation of electron-rich arenes.
以选择性方式直接对芳烃的C-H键进行烷基化是一个长期存在的挑战。在此，开发了一种无金属光催化区域选择性C-H烷基化方法，用于富电子芳烃与活化和未活化烯烃的反应。该反应适用于具有各种取代模式的广泛芳环以及末端和内烯烃，为从惰性C-H键形成C-C键提供了一种通用且直接的无金属方法。此外，炔烃也适用于富电子芳烃的C-H乙烯基化反应。
